Xiao Yu, Yang Junfeng, Yang Maolin, Len Jinjun, Yu Yanhong
The Affiliated Hospital, Kunming University of Science and Technology, Kunming, China.
Department of Urology, The First People's Hospital of Yunnan Province, Kunming, YN, China.
Front Genet. 2022 Aug 8;13:866819. doi: 10.3389/fgene.2022.866819. eCollection 2022.
Clear cell renal cell carcinoma (ccRCC) is one of the most common tumors in the urinary system. ccRCC has obvious immunological characteristics, and the infiltration of immune cells is related to the prognosis of ccRCC. The effect of immune checkpoint therapy is related to the dynamic changes of the tumor immune microenvironment (TIM). The 7-methylguanosine (m7G) is an additional mRNA modification ability besides m6A, which is closely related to the TIM and affects the occurrence and development of tumors. At present, the correlations between m7G and the immune microenvironment, treatment, and prognosis of ccRCC are not clear. As far as we know, there was no study on the relationship between m7G and the immune microenvironment and survival of clear cell renal cell carcinomas. A comprehensive analysis of the correlations between them and the construction of a prognosis model are helpful to improve the treatment strategy. Two different molecular subtypes were identified in 539 ccRCC samples by describing the differences of 29 m7G-related genes. It was found that the clinical features, TIM, and prognosis of ccRCC patients were correlated with the m7G-related genes. We found that there were significant differences in the expression of PD-1, CTLA4, and PD-L1 between high- and low-risk groups. To sum up, m7G-related genes play a potential role in the TIM, treatment, and prognosis of ccRCC. Our results provide new findings for ccRCC and help to improve the immunotherapy strategies and prognosis of patients.
透明细胞肾细胞癌（ccRCC）是泌尿系统最常见的肿瘤之一。ccRCC具有明显的免疫特征，免疫细胞浸润与ccRCC的预后相关。免疫检查点治疗的效果与肿瘤免疫微环境（TIM）的动态变化有关。7-甲基鸟苷（m7G）是除m6A之外的另一种mRNA修饰能力，其与TIM密切相关并影响肿瘤的发生发展。目前，m7G与ccRCC的免疫微环境、治疗及预后之间的相关性尚不清楚。据我们所知，尚无关于m7G与透明细胞肾细胞癌免疫微环境及生存关系的研究。对它们之间的相关性进行综合分析并构建预后模型有助于改善治疗策略。通过描述29个与m7G相关基因的差异，在539例ccRCC样本中鉴定出两种不同的分子亚型。发现ccRCC患者的临床特征、TIM和预后与m7G相关基因有关。我们发现高危组和低危组之间PD-1、CTLA4和PD-L1的表达存在显著差异。综上所述，m7G相关基因在ccRCC的TIM、治疗和预后中发挥潜在作用。我们的结果为ccRCC提供了新的发现，并有助于改善患者的免疫治疗策略和预后。
