Department of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, China.
Department of Clinical Medicine, Mudanjiang Medical University, Mudanjiang, China.
Front Immunol. 2022 Aug 8;13:916778. doi: 10.3389/fimmu.2022.916778. eCollection 2022.
Proallergic type 2 helper T (Th2A) cells are a subset of memory Th2 cells confined to atopic individuals, and they include all the allergen-specific Th2 cells. Recently, many studies have shown that Th2A cells characterized by CD3 CD4 HPGDS CRTH2 CD161 ST2 CD49d CD27 play a crucial role in allergic diseases, such as atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), asthma, and eosinophilic esophagitis (EoE). In this review, we summarize the discovery, biomarkers, and biological properties of Th2A cells to gain new insights into the pathogenesis of allergic diseases.
原发型 2 型辅助 T（Th2A）细胞是局限于特应性个体的记忆性 Th2 细胞的一个亚群，它们包含所有的过敏原特异性 Th2 细胞。最近，许多研究表明，具有 CD3 CD4 HPGDS CRTH2 CD161 ST2 CD49d CD27 特征的 Th2A 细胞在过敏性疾病（如特应性皮炎（AD）、食物过敏（FA）、过敏性鼻炎（AR）、哮喘和嗜酸性食管炎（EoE））中发挥着关键作用。在这篇综述中，我们总结了 Th2A 细胞的发现、生物标志物和生物学特性，以深入了解过敏性疾病的发病机制。
