Ge Xia, Wang Ling, Fei Aihua, Ye Shandong, Zhang Qingping
Department of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.
Graduate School of Anhui University of Chinese Medicine, Hefei, China.
Front Physiol. 2022 Aug 8;13:956344. doi: 10.3389/fphys.2022.956344. eCollection 2022.
Diabetes is a common metabolic disease whose hyperglycemic state can induce diverse complications and even threaten human health and life security. Currently, the treatment of diabetes is restricted to drugs that regulate blood glucose and have certain accompanying side effects. Autophagy, a research hotspot, has been proven to be involved in the occurrence and progression of the chronic complications of diabetes. Autophagy, as an essential organismal defense mechanism, refers to the wrapping of cytoplasmic proteins, broken organelles or pathogens by vesicles, which are then degraded by lysosomes to maintain the stability of the intracellular environment. Here, we review the relevant aspects of autophagy and the molecular mechanisms of autophagy in diabetic chronic complications, and further analyze the impact of improving autophagy on diabetic chronic complications, which will contribute to a new direction for further prevention and treatment of diabetic chronic complications.
糖尿病是一种常见的代谢性疾病，其高血糖状态可引发多种并发症，甚至威胁人类健康和生命安全。目前，糖尿病的治疗局限于调节血糖的药物，且这些药物存在一定的副作用。自噬作为一个研究热点，已被证明与糖尿病慢性并发症的发生和发展有关。自噬作为一种重要的机体防御机制，是指细胞质中的蛋白质、破损的细胞器或病原体被囊泡包裹，然后由溶酶体进行降解，以维持细胞内环境的稳定。在此，我们综述自噬的相关方面以及自噬在糖尿病慢性并发症中的分子机制，并进一步分析改善自噬对糖尿病慢性并发症的影响，这将为进一步防治糖尿病慢性并发症提供新的方向。
