Instituto de Bioquimica y Medicina Molecular Prof. Alberto Boveris (UBA-CONICET), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires C1113 AAD, Argentina.
Instituto Universitario del Centro de Educacion Medica e Investigacion Clinica (IUC-CEMIC-CONICET), Facultad de Medicina, Instituto Universitario CEMIC, Buenos Aires C1430 EFA, Argentina.
Cells. 2021 Sep 21;10(9):2497. doi: 10.3390/cells10092497.
Diabetic kidney disease (DKD) is a frequent, potentially devastating complication of diabetes mellitus. Several factors are involved in its pathophysiology. At a cellular level, diabetic kidney disease is associated with many structural and functional alterations. Autophagy is a cellular mechanism that transports intracytoplasmic components to lysosomes to preserve cellular function and homeostasis. Autophagy integrity is essential for cell homeostasis, its alteration can drive to cell damage or death. Diabetic kidney disease is associated with profound autophagy dysregulation. Autophagy rate and flux alterations were described in several models of diabetic kidney disease. Some of them are closely linked with disease progression and severity. Some antidiabetic agents have shown significant effects on autophagy. A few of them have also demonstrated to modify disease progression and improved outcomes in affected patients. Other drugs also target autophagy and are being explored for clinical use in patients with diabetic kidney disease. The modulation of autophagy could be relevant for the pharmacological treatment and prevention of this disease in the future. Therefore, this is an evolving area that requires further experimental and clinical research. Here we discuss the relationship between autophagy and Diabetic kidney disease and the potential value of autophagy modulation as a target for pharmacological intervention.
糖尿病肾病（DKD）是糖尿病的一种常见且潜在的严重并发症。其发病机制涉及多种因素。在细胞水平上，糖尿病肾病与许多结构和功能的改变有关。自噬是一种将细胞内成分运输到溶酶体以维持细胞功能和内稳态的细胞机制。自噬完整性对于细胞内稳态至关重要，其改变可导致细胞损伤或死亡。糖尿病肾病与深刻的自噬失调有关。在几种糖尿病肾病模型中描述了自噬率和通量的改变。其中一些与疾病进展和严重程度密切相关。一些抗糖尿病药物对自噬有显著影响。其中一些药物也已被证明可以改善受影响患者的疾病进展和预后。其他药物也针对自噬，并正在探索用于糖尿病肾病患者的临床应用。自噬的调节可能与这种疾病的未来药物治疗和预防有关。因此，这是一个正在发展的领域，需要进一步的实验和临床研究。在这里，我们讨论了自噬与糖尿病肾病的关系，以及自噬调节作为药物干预靶点的潜在价值。
