Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, China.
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 10016, PR China.
Org Biomol Chem. 2022 Sep 14;20(35):7076-7084. doi: 10.1039/d2ob01242a.
Twenty-two cephalotaxine-type and ten homoerythrina-type alkaloids, including seven previously undescribed ones, were isolated from the twigs and leaves and the seed kernels of . Their structures were established by spectroscopic analysis, single crystal X-ray diffraction, and ECD calculation methods. Cephalofortunine A β--oxide (1) is the first nitrogen-oxidized homoerythrina-type alkaloid. The isolated compounds were evaluated for their antiproliferative effects against two human leukemia cell lines (THP-1 and K562). All compounds showed different levels of antiproliferation in THP-1 and K562 cells with GI values of 0.24-29.55 μM. Hainanensine (31) was the most active against two cancer cell lines with GI values of 0.24 ± 0.07, and 0.29 ± 0.01 μM, respectively.
从. 的嫩枝和叶片以及种仁中分离得到了 22 种三尖杉型和 10 种石蒜型生物碱，其中包括 7 种以前未描述过的生物碱。通过光谱分析、单晶 X 射线衍射和 ECD 计算方法确定了它们的结构。Cephalofortunine A β-氧化物（1）是第一个氮氧化的石蒜型生物碱。对分离得到的化合物进行了抗两种人白血病细胞系（THP-1 和 K562）的增殖活性评价。所有化合物在 THP-1 和 K562 细胞中均表现出不同程度的增殖抑制作用，GI 值为 0.24-29.55 μM。Hainanensine（31）对两种癌细胞系的活性最高，GI 值分别为 0.24±0.07 和 0.29±0.01 μM。
