Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, P. R. China.
Chem Biodivers. 2013 Apr;10(4):584-95. doi: 10.1002/cbdv.201200105.
A phytochemical investigation of the branches and leaves of Cephalotaxus lanceolata resulted in the isolation of three new cephalotaxus alkaloids, cephalancetines A, B, and D (1, 2, and 4, resp.), together with ten known alkaloids, 3 and 5-13. The structures of the alkaloids were elucidated on the basis of spectroscopic analyses, including 1D- and 2D-NMR, and HR-ESI-MS, and single-crystal X-ray diffraction. All isolated compounds were tested for their cytotoxicities against four human tumor cell lines, A549, HCT116, SK-BR-3, and HepG2. Compounds 12 and 13 showed remarkable activities against A549, HCT116, and HepG2 cell lines.
从龙牙木的枝叶中分离得到三个新的三尖杉生物碱，即 Cephalancetine A、B 和 D（1、2 和 4），以及十个已知的生物碱，即 3 和 5-13。基于光谱分析，包括 1D 和 2D-NMR 和 HR-ESI-MS，以及单晶 X 射线衍射，阐明了生物碱的结构。所有分离得到的化合物均对四种人肿瘤细胞系 A549、HCT116、SK-BR-3 和 HepG2 进行了细胞毒性测试。化合物 12 和 13 对 A549、HCT116 和 HepG2 细胞系表现出显著的活性。
