Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education), School of Medicine and Health, Harbin Institute of Technology, No. 92 XiDaZhi Street, 150001, Harbin, P. R. China.
Wenzhou Institute, University of Chinese Academy of Sciences, 1 Jinlian Street, 325000, Wenzhou, P. R. China.
Chemistry. 2022 Dec 1;28(67):e202202319. doi: 10.1002/chem.202202319. Epub 2022 Sep 23.
Chemotaxis plays a crucial role in the realization of various functions of human life such as fertilization, immune function, inflammatory response, regeneration processes, etc. Inspired by the natural chemotaxis, colloidal motors with chemotactic ability can realize intelligent sense and targeted navigation, which bring a revolutionary method to biomedical applications like precision medicine. However, the application in the biomedical field requires the colloidal motors with submicrometer scale, strong chemotactic ability and clear chemotactic mechanism. In this Concept article, we introduce the recent progress of chemotactic colloidal motors, covering the fundamental theory behind experimental advancements. Particularly, the torque-driven reorientation motion of the submicrometer-sized colloidal motors during chemotaxis is discussed, and also their underlying mechanism is proposed. With the continuous research on chemotactic colloidal motors, it is believed that the emerging chemotactic colloidal motors will broaden practical applications in the biomedical field.
趋化作用在人类生命的各种功能的实现中起着至关重要的作用，例如受精、免疫功能、炎症反应、再生过程等。受自然趋化作用的启发，具有趋化能力的胶体马达可以实现智能感知和靶向导航，为精准医疗等生物医学应用带来了革命性的方法。然而，在生物医学领域的应用需要亚微米级、强趋化能力和明确趋化机制的胶体马达。在这篇概念文章中，我们介绍了趋化胶体马达的最新进展，涵盖了实验进展背后的基本理论。特别是，讨论了亚微米胶体马达在趋化作用下的扭矩驱动重定向运动及其潜在机制。随着对趋化胶体马达的不断研究，相信新兴的趋化胶体马达将拓宽其在生物医学领域的实际应用。
