Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education), School of Medicine and Health, Harbin Institute of Technology, No. 92 XiDaZhi Street, Harbin, 150001, China.
Nanoscale. 2022 Sep 15;14(35):12547-12559. doi: 10.1039/d2nr03963j.
Colloidal motors have unique capabilities of self-propulsion, cargo loading and active target delivery, and have great potential for precision disease therapy. Currently, colloidal motors with different functions have been designed for diverse disease treatments. However, the application of colloidal motors in precision disease treatment is still in the exploratory stage and faces many practical challenges. This review highlights the therapeutic functions of colloidal motors, such as anti-cancer, anti-bacterial, anti-inflammation, hypoglycemic, immune activation and hemostasis functions. Furthermore, the application progress of multifunctional colloidal motors in various diseases has also been summarized, including cerebral diseases, ophthalmic diseases, gastrointestinal diseases, cardiovascular diseases and bladder diseases. Finally, the current limitations and challenges of colloidal motors as well as future research directions are discussed. This review aims to help readers become clearly acquainted with the achievements of colloidal motors that have been made in disease treatment and to promote the further development of colloidal motors in clinical medicine.
胶粒马达具有自主推进、负载货物和主动靶向投递的独特能力，在精准疾病治疗方面具有巨大的潜力。目前，已经设计出具有不同功能的胶粒马达，用于不同的疾病治疗。然而，胶粒马达在精准疾病治疗中的应用仍处于探索阶段，面临着许多实际挑战。本综述强调了胶粒马达的治疗功能，如抗癌、抗菌、抗炎、降血糖、免疫激活和止血功能。此外，还总结了多功能胶粒马达在各种疾病中的应用进展，包括脑部疾病、眼部疾病、胃肠道疾病、心血管疾病和膀胱疾病。最后，讨论了胶粒马达目前的局限性和挑战以及未来的研究方向。本综述旨在帮助读者清楚地了解胶粒马达在疾病治疗方面所取得的成就，并促进胶粒马达在临床医学中的进一步发展。
