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[青光眼手术中伤口愈合的药理学调节]

[Pharmacological modulation of wound healing in glaucoma surgery].

作者信息

Malyugin B E, Sidorova A V, Starostina A V, Zhuravlev A S, Khaletskaya A A, Eliseeva M A, Smirnova E A

机构信息

S.N. Fedorov National Medical Research Center "MNTK "Eye Microsurgery", Moscow, Russia.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.

出版信息

Vestn Oftalmol. 2022;138(4):136-143. doi: 10.17116/oftalma2022138041136.

Abstract

Despite the well-known effectiveness of pharmacological glaucoma therapy, surgical approach remains one of the main treatment options for some forms and stages of the disease. The long-term success of glaucoma surgery depends on the intensity of local wound healing processes at the surgical site. The most common way to influence healing processes in surgical treatment of glaucoma is the use of antimetabolites. However, given the high risk of serious complications associated with their use, the search for new drugs devoid of these disadvantages continues. The aim of this review is to describe the efficacy and safety of both currently used and upcoming pharmacological ways to influence the wound healing process after glaucoma surgery in order to improve the stability of hypotensive effect.

摘要

尽管药物性青光眼治疗的有效性广为人知,但手术方法仍是该疾病某些形式和阶段的主要治疗选择之一。青光眼手术的长期成功取决于手术部位局部伤口愈合过程的强度。青光眼手术治疗中影响愈合过程最常见的方法是使用抗代谢物。然而,鉴于使用抗代谢物会带来严重并发症的高风险,人们仍在继续寻找没有这些缺点的新药。本综述的目的是描述目前使用的以及即将出现的影响青光眼手术后伤口愈合过程的药理学方法的疗效和安全性,以提高降压效果的稳定性。

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