Chang M R, Cheng Q, Lee D A
Jules Stein Eye Institute, Department of Opthalmology, UCLA School of Medicine, Los Angeles, California 90095-7004, USA.
J Ocul Pharmacol Ther. 1998 Feb;14(1):75-95. doi: 10.1089/jop.1998.14.75.
Success of glaucoma filtration surgery is influenced by the wound healing response. Attention has been focused on pharmacological agents to control a process that leads to excessive scarring and eventual failure of glaucoma filtration surgery. Several agents, including 5-fluorouracil and mitomycin C, as well as other antiproliferative drugs will be discussed. Newer antifibrotic agents and novel drug delivery systems are under development in tissue culture and animal models in an effort to improve efficacy and safety. This article summarizes current treatment modalities and future prospects to prevent excessive wound healing and improve the success of glaucoma filtration surgery.
青光眼滤过手术的成功受到伤口愈合反应的影响。人们已将注意力集中在控制导致过度瘢痕形成并最终致使青光眼滤过手术失败过程的药物上。将讨论几种药物，包括5-氟尿嘧啶、丝裂霉素C以及其他抗增殖药物。为了提高疗效和安全性，新型抗纤维化药物和新型给药系统正在组织培养和动物模型中研发。本文总结了当前预防过度伤口愈合并提高青光眼滤过手术成功率的治疗方式及未来前景。
