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海洋节肢动物作为抗菌肽的来源。

Marine Arthropods as a Source of Antimicrobial Peptides.

机构信息

CATS Research Group, School of Chemical Sciences & Engineering, Yachay Tech University, Hda. San José s/n y Proyecto Yachay, Urcuquí 100119, Ecuador.

School of Biological Sciences & Engineering, Yachay Tech University, Hda. San José s/n y Proyecto Yachay, Urcuquí 100119, Ecuador.

出版信息

Mar Drugs. 2022 Aug 2;20(8):501. doi: 10.3390/md20080501.

DOI:10.3390/md20080501
PMID:36005504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9409781/
Abstract

Peptide therapeutics play a key role in the development of new medical treatments. The traditional focus on endogenous peptides has shifted from first discovering other natural sources of these molecules, to later synthesizing those with unique bioactivities. This review provides concise information concerning antimicrobial peptides derived from marine crustaceans for the development of new therapeutics. Marine arthropods do not have an adaptive immune system, and therefore, they depend on the innate immune system to eliminate pathogens. In this context, antimicrobial peptides (AMPs) with unique characteristics are a pivotal part of the defense systems of these organisms. This review covers topics such as the diversity and distribution of peptides in marine arthropods (crustacea and chelicerata), with a focus on penaeid shrimps. The following aspects are covered: the defense system; classes of AMPs; molecular characteristics of AMPs; AMP synthesis; the role of penaeidins, anti-lipopolysaccharide factors, crustins, and stylicins against microorganisms; and the use of AMPs as therapeutic drugs. This review seeks to provide a useful compilation of the most recent information regarding AMPs from marine crustaceans, and describes the future potential applications of these molecules.

摘要

肽类治疗药物在新医疗手段的发展中起着关键作用。传统上对内源性肽的关注已经从最初发现这些分子的其他天然来源，转移到后来合成具有独特生物活性的肽。本综述提供了有关源自海洋甲壳类动物的抗菌肽的简明信息，用于开发新的治疗方法。海洋节肢动物没有适应性免疫系统，因此，它们依赖于先天免疫系统来消除病原体。在这种情况下，具有独特特性的抗菌肽 (AMPs) 是这些生物防御系统的关键部分。本综述涵盖了海洋节肢动物（甲壳类和螯肢类）中肽的多样性和分布等主题，重点介绍了对虾属虾类。涵盖的方面包括：防御系统；AMPs 的类别；AMPs 的分子特征；AMPs 的合成；对虾肽、抗脂多糖因子、甲壳质和 stylicins 对微生物的作用；以及 AMPs 作为治疗药物的应用。本综述旨在提供有关海洋甲壳类动物抗菌肽的最新信息的有用汇编，并描述了这些分子的未来潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/a601624c0e26/marinedrugs-20-00501-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/89f7d455acd9/marinedrugs-20-00501-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/d771f02ec202/marinedrugs-20-00501-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/cb0a1b702d8e/marinedrugs-20-00501-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/19b5f939ac32/marinedrugs-20-00501-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/7a3a20df670d/marinedrugs-20-00501-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/9beb5a273fda/marinedrugs-20-00501-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/a601624c0e26/marinedrugs-20-00501-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/ac7d0fa5ed94/marinedrugs-20-00501-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/2bcd21809358/marinedrugs-20-00501-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/834fce0edc93/marinedrugs-20-00501-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/a583d740628b/marinedrugs-20-00501-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/97281941bff9/marinedrugs-20-00501-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/89f7d455acd9/marinedrugs-20-00501-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/d771f02ec202/marinedrugs-20-00501-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/cb0a1b702d8e/marinedrugs-20-00501-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/19b5f939ac32/marinedrugs-20-00501-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/7a3a20df670d/marinedrugs-20-00501-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/9beb5a273fda/marinedrugs-20-00501-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50bf/9409781/a601624c0e26/marinedrugs-20-00501-g012.jpg

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