Department of Pharmacy, Changzhi Medical College, 046000, Changzhi, P. R. China.
Department of Materials Science and Engineering, Jinzhong University, 030619, Jinzhong, P. R. China.
ChemistryOpen. 2022 Aug;11(8):e202200097. doi: 10.1002/open.202200097.
Sulfonamides have a special role on medicine due to their broad biological activities, as bacterial infections, diabetes mellitus, oedema, hypertension prevention and treatment. In addition, sulfonamides are also useful in herbicides and pesticides. Herein, we communicate an efficient strategy for the preparation of sulfonamides via NH I-mediated amination of sodium sulfinates. This new method provides a general and environmentally friendly access to sulfonamide compounds and tolerates a wide range of functional groups.
磺胺类药物由于其广泛的生物活性，如细菌感染、糖尿病、水肿、高血压的预防和治疗，在医学上具有特殊的作用。此外，磺胺类药物在除草剂和杀虫剂中也很有用。在此，我们通过 NH I 介导的磺酸钠的氨化来沟通一种制备磺胺类药物的有效策略。这种新方法为磺胺类化合物提供了一种通用且环保的方法，并能耐受广泛的官能团。
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