School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
Chem Commun (Camb). 2013 Jul 11;49(54):6102-4. doi: 10.1039/c3cc41249k.
A new and convenient method for the construction of sulfonamides via a copper-catalyzed oxidative coupling between sodium sulfinates and amines with 1 atm O2 or DMSO as the oxidant was described. This method provides efficient and robust synthesis of functional sulfonamides in good yields and excellent chemoselectivity. And detailed mechanistic studies showed that this transformation may go through a single electron transfer (SET) pathway.
本文描述了一种新的、方便的方法，通过亚磺酸钠盐和胺之间的铜催化氧化偶联，在 1 大气压 O2 或 DMSO 作为氧化剂的条件下构建磺酰胺。该方法提供了高效、稳健的功能磺酰胺合成，产率高，化学选择性好。详细的机理研究表明，这种转化可能经过单电子转移（SET）途径。
