Zawieja Emilia, Durkalec-Michalski Krzysztof, Muzsik-Kazimierska Agata, Chmurzynska Agata
Department of Human Nutrition and Dietetics, Poznan University of Life Sciences, 60-624 Poznan, Poland.
Department of Sports Dietetics, Poznan University of Physical Education, 61-871 Poznan, Poland.
Metabolites. 2022 Aug 7;12(8):731. doi: 10.3390/metabo12080731.
Betaine (BET) supplementation decreases homocysteine concentration in plasma, but it may also have an adverse effect on health by increasing blood lipid concentrations, at least in overweight and obese individuals. The aim of this study was to evaluate the effect of BET supplementation on the lipid profile and concentrations of homocysteine, inflammatory cytokines, and liver enzymes in physically active, healthy males. This was a randomized, placebo (PL)-controlled, double-blinded, crossover trial. BET (2.5 or 5.0 g/d) was administered for 21 days. Before and after supplementation with BET or PL, anthropometric measurements and blood were collected in a fasted state. Our results show that BET supplementation significantly decreased homocysteine concentration (from 17.1 ± 4.0 μmol/L before BET to 15.6 ± 3.5 μmol/L after BET, = 0.009, η = 0.164). However, the intervention had no effect on total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerol, interleukins 1β and 6, and tumour necrosis factor α concentrations, or alanine and aspartate activities. In addition, there were no interactions between the genotype and BET dose. In conclusion, BET supplementation may be beneficial for homocysteine concentration in healthy, physically active males, with no detrimental effect on lipid profile.
补充甜菜碱（BET）可降低血浆中的同型半胱氨酸浓度，但至少在超重和肥胖个体中，它也可能通过升高血脂浓度对健康产生不利影响。本研究的目的是评估补充BET对身体活跃的健康男性的血脂谱、同型半胱氨酸浓度、炎性细胞因子和肝酶的影响。这是一项随机、安慰剂（PL）对照、双盲、交叉试验。给予BET（2.5或5.0 g/天），持续21天。在补充BET或PL之前和之后，在禁食状态下进行人体测量并采集血液。我们的结果表明，补充BET可显著降低同型半胱氨酸浓度（从BET前的17.1±4.0μmol/L降至BET后的15.6±3.5μmol/L，P = 0.009，η = 0.164）。然而，该干预对总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、三酰甘油、白细胞介素1β和6以及肿瘤坏死因子α浓度或丙氨酸和天冬氨酸活性没有影响。此外，基因分型与BET剂量之间没有相互作用。总之，补充BET可能有益于健康、身体活跃男性的同型半胱氨酸浓度，对血脂谱没有不利影响。
