Oueijan Rana I, Hill Olivia R, Ahiawodzi Peter D, Fasinu Pius S, Thompson Dorothea K
School of Pharmacy, College of Pharmacy and Health Sciences, Campbell University, Buies Creek, NC 27501, USA.
Department of Public Health, College of Pharmacy and Health Sciences, Campbell University, Buies Creek, NC 27501, USA.
Medicines (Basel). 2022 Aug 11;9(8):43. doi: 10.3390/medicines9080043.
Since the successful development, approval, and administration of vaccines against SARS-CoV-2, the causative agent of COVID-19, there have been reports in the published literature, passive surveillance systems, and other pharmacovigilance platforms of a broad spectrum of adverse events following COVID-19 vaccination. A comprehensive review of the more serious adverse events associated with the Pfizer-BioNTech and Moderna mRNA vaccines is warranted, given the massive number of vaccine doses administered worldwide and the novel mechanism of action of these mRNA vaccines in the healthcare industry. A systematic review of the literature was conducted to identify relevant studies that have reported mRNA COVID-19 vaccine-related adverse events. Serious and severe adverse events following mRNA COVID-19 vaccinations are rare. While a definitive causal relationship was not established in most cases, important adverse events associated with post-vaccination included rare and non-fatal myocarditis and pericarditis in younger vaccine recipients, thrombocytopenia, neurological effects such as seizures and orofacial events, skin reactions, and allergic hypersensitivities. As a relatively new set of vaccines already administered to billions of people, COVID-19 mRNA-based vaccines are generally safe and efficacious. Further studies on long-term adverse events and other unpredictable reactions in close proximity to mRNA vaccination are required.
自从针对2019冠状病毒病的病原体严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的疫苗成功研发、获批并投入使用以来，已发表的文献、被动监测系统及其他药物警戒平台均有关于接种新冠疫苗后出现广泛不良事件的报告。鉴于全球范围内大量接种了疫苗，且这些信使核糖核酸（mRNA）疫苗在医疗行业中的作用机制新颖，有必要对与辉瑞-生物科技公司和莫德纳公司的mRNA疫苗相关的更严重不良事件进行全面综述。我们对文献进行了系统回顾，以确定报告了与mRNA新冠疫苗相关不良事件的相关研究。接种mRNA新冠疫苗后出现的严重和重度不良事件较为罕见。虽然在大多数情况下未确立明确的因果关系，但与接种疫苗后相关的重要不良事件包括较年轻的疫苗接种者出现罕见且非致命的心肌炎和心包炎、血小板减少症、癫痫发作和口面部症状等神经学效应、皮肤反应以及过敏性超敏反应。作为已经接种了数十亿人的相对较新的一类疫苗，基于mRNA的新冠疫苗总体上是安全有效的。需要对mRNA疫苗接种后不久出现的长期不良事件和其他不可预测的反应进行进一步研究。
