Meumann Ella M, Krause Vicki L, Baird Robert, Currie Bart J
Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin 0810, Australia.
Department of Infectious Diseases, Division of Medicine, Royal Darwin Hospital, Darwin 0810, Australia.
Trop Med Infect Dis. 2022 Aug 12;7(8):181. doi: 10.3390/tropicalmed7080181.
The Northern Territory (NT) is a geographically remote region of northern and central Australia. Approximately a third of the population are First Nations Australians, many of whom live in remote regions. Due to the physical environment and climate, and scale of social inequity, the rates of many infectious diseases are the highest nationally. Molecular typing and genomic sequencing in research and public health have provided considerable new knowledge on the epidemiology of infectious diseases in the NT. We review the applications of genomic sequencing technology for molecular typing, identification of transmission clusters, phylogenomics, antimicrobial resistance prediction, and pathogen detection. We provide examples where these methodologies have been applied to infectious diseases in the NT and discuss the next steps in public health implementation of this technology.
北领地（NT）是澳大利亚北部和中部一个地理位置偏远的地区。大约三分之一的人口是澳大利亚原住民，其中许多人生活在偏远地区。由于自然环境、气候以及社会不平等的程度，许多传染病的发病率在全国范围内是最高的。研究和公共卫生领域的分子分型和基因组测序为北领地传染病流行病学提供了大量新知识。我们综述了基因组测序技术在分子分型、传播集群识别、系统发育基因组学、抗菌药物耐药性预测和病原体检测方面的应用。我们列举了这些方法应用于北领地传染病的实例，并讨论了该技术在公共卫生实施方面的下一步举措。
