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主要组织相容性复合体II类基因表达不同功能状态下HLA - DRα基因的染色质结构

Chromatin structure of the HLA-DR alpha gene in different functional states of major histocompatibility complex class II gene expression.

作者信息

Peterlin B M, Hardy K J, Larsen A S

出版信息

Mol Cell Biol. 1987 May;7(5):1967-72. doi: 10.1128/mcb.7.5.1967-1972.1987.

DOI:10.1128/mcb.7.5.1967-1972.1987
PMID:3600654
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC365303/
Abstract

We utilized DNase I hypersensitivity mapping to study chromatin structure within the HLA-DR alpha gene. We found a single DNase I-hypersensitive site coinciding with the HLA-DR alpha gene promoter in all cells studied. Moreover, in cells that constitutively express HLA-DR, two additional DNase I-hypersensitive sites were observed. These lie within the first intron of the HLA-DR alpha gene and encompass DNA sequences that share homologies with regulatory loci of the immunoglobulin and immune response genes, as well as with core enhancer consensus sequences.

摘要

我们利用DNA酶I超敏作图来研究HLA - DRα基因内的染色质结构。我们发现在所有研究的细胞中，有一个单一的DNA酶I超敏位点与HLA - DRα基因启动子重合。此外，在组成性表达HLA - DR的细胞中，还观察到另外两个DNA酶I超敏位点。它们位于HLA - DRα基因的第一个内含子内，包含与免疫球蛋白和免疫反应基因的调控位点以及核心增强子共有序列具有同源性的DNA序列。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ba/365303/c954e2af7a9e/molcellb00077-0397-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ba/365303/97ac0e217b63/molcellb00077-0396-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ba/365303/3335210b4f89/molcellb00077-0396-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ba/365303/c954e2af7a9e/molcellb00077-0397-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ba/365303/97ac0e217b63/molcellb00077-0396-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ba/365303/3335210b4f89/molcellb00077-0396-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ba/365303/c954e2af7a9e/molcellb00077-0397-a.jpg

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Transcriptional enhancers in the HLA-DQ subregion.HLA-DQ亚区域中的转录增强子。
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Inherited immunodeficiency with a defect in a major histocompatibility complex class II promoter-binding protein differs in the chromatin structure of the HLA-DRA gene.一种主要组织相容性复合体II类启动子结合蛋白存在缺陷的遗传性免疫缺陷，其HLA - DRA基因的染色质结构有所不同。
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