Krause M, Pfüller H, Herbst D, Kruse K
Monatsschr Kinderheilkd. 1987 Apr;135(4):200-3.
In 1982 Johnson et al. described a simple colorimetric assay for measuring glycated proteins, termed fructosamine, in the serum of adults with diabetes mellitus and demonstrated this to be a useful index of intermediate glucose control (1-3 weeks). Our study was designed to show this as well in children and adolescents with type I diabetes mellitus. Serum fructosamine was determined in 76 children and adolescents with diabetes mellitus, and 111 age-matched controls. In the controls an age-dependency but not sex-dependency could be demonstrated. In the diabetic patients we found a significant correlation between serum fructosamine and HbA1 values (r = 0.87, p less than 0.001). In 6 patients with newly diagnosed diabetes mellitus serum fructosamine concentrations decreased at a faster rate than HbA1 values. The fructosamine assay is rapid, technically simple and inexpensive, and is at least a useful addition or perhaps an alternative to HbA1 estimation.
1982年，约翰逊等人描述了一种简单的比色法，用于测量糖尿病成年患者血清中的糖化蛋白，即果糖胺，并证明这是一个反映血糖中期控制情况（1 - 3周）的有用指标。我们的研究旨在证明这一指标在1型糖尿病儿童和青少年中同样适用。我们测定了76例糖尿病儿童和青少年以及111例年龄匹配的对照者的血清果糖胺。在对照组中，可证明存在年龄依赖性，但不存在性别依赖性。在糖尿病患者中，我们发现血清果糖胺与糖化血红蛋白（HbA1）值之间存在显著相关性（r = 0.87，p < 0.001）。在6例新诊断的糖尿病患者中，血清果糖胺浓度下降速度比HbA1值更快。果糖胺检测快速、技术操作简单且成本低廉，至少是糖化血红蛋白估计的一个有用补充，或许也可作为替代方法。
