Guillausseau P J, Charles M A, Godard V, Timsit J, Chanson P, Paolaggi F, Peynet J, Eschwege E, Rousselet F, Lubetzki J
Department of Diabetology, Hospital Lariboisière, Paris, France.
Diabetes Res. 1990 Mar;13(3):127-31.
Fasting and postprandial (or post-glucose load) plasma glucose, total HbA1 and fructosamine (F) were simultaneously assessed in 371 diabetic patients (125 insulin dependent and 246 non-insulin dependent) and in 122 nondiabetic subjects, (98 with normal glucose tolerance and 24 with impaired glucose tolerance). Fructosamine yielded nearly similar information as HbA1 about glycemic control, since similar relationships were observed between plasma glucose values and HbA1 or fructosamine levels in the different groups. A longitudinal study performed during a three-month follow-up in 74 diabetic patients and extended to six months in 19 of them, without any modification of treatment, indicated that reproducibility of HbA1 and fructosamine was nearly the same with a slight advantage for HbA1. The only clinically significant difference results from the longer half-life of hemoglobin when compared to serum proteins. Fructosamine assay should be proposed as a complement of HbA1 in the management of diabetic patients when detection of recent metabolic changes is needed.
对371例糖尿病患者（125例胰岛素依赖型和246例非胰岛素依赖型）以及122例非糖尿病受试者（98例葡萄糖耐量正常和24例葡萄糖耐量受损）同时进行空腹及餐后（或葡萄糖负荷后）血糖、总糖化血红蛋白（HbA1）和果糖胺（F）的评估。果糖胺提供的关于血糖控制的信息与HbA1几乎相似，因为在不同组中观察到血浆葡萄糖值与HbA1或果糖胺水平之间存在相似的关系。在74例糖尿病患者中进行的为期三个月的随访纵向研究，并将其中19例延长至六个月，且未对治疗进行任何调整，结果表明HbA1和果糖胺的可重复性几乎相同，HbA1略有优势。唯一具有临床意义的差异源于血红蛋白与血清蛋白相比半衰期更长。当需要检测近期代谢变化时，应建议将果糖胺测定作为糖尿病患者管理中HbA1的补充。
