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达格列净治疗射血分数降低的心力衰竭患者。

Dapagliflozin for patients with heart failure and reduced ejection fraction.

机构信息

Abigail Ferry practices in the division of advanced heart failure and cardiac transplant at Allegheny General Hospital in Pittsburgh, Pa. The author has disclosed no potential conflicts of interest, financial or otherwise.

出版信息

JAAPA. 2022 Sep 1;35(9):51-53. doi: 10.1097/01.JAA.0000840504.15807.70.

DOI:10.1097/01.JAA.0000840504.15807.70
PMID:36007119
Abstract

The CDC estimates that national costs related to heart failure exceed $30 billion annually. Clinicians and researchers continue to aggressively pursue measures aimed at reducing morbidity and mortality among the 6.5 million adults affected by the disease. Dapagliflozin recently emerged as a promising FDA-approved therapy for patients with systolic heart failure, more commonly referred to as heart failure with reduced ejection fraction.

摘要

美国疾病控制与预防中心估计,每年与心力衰竭相关的国家成本超过 300 亿美元。临床医生和研究人员继续积极寻求降低 650 万受这种疾病影响的成年人发病率和死亡率的措施。达格列净最近成为一种有前途的 FDA 批准的治疗收缩性心力衰竭(更常称为射血分数降低的心力衰竭)患者的疗法。

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1
Dapagliflozin for patients with heart failure and reduced ejection fraction.达格列净治疗射血分数降低的心力衰竭患者。
JAAPA. 2022 Sep 1;35(9):51-53. doi: 10.1097/01.JAA.0000840504.15807.70.
2
Time to Clinical Benefit of Dapagliflozin and Significance of Prior Heart Failure Hospitalization in Patients With Heart Failure With Reduced Ejection Fraction.达格列净的临床获益时间和心力衰竭射血分数降低患者既往心力衰竭住院的意义。
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Impact of Dapagliflozin on Mortality in Patients With Heart Failure and Reduced Ejection Fraction: A Meta-analysis.达格列净对射血分数降低的心力衰竭患者死亡率的影响:一项荟萃分析。
Am J Ther. 2022;29(5):e578-e579. doi: 10.1097/MJT.0000000000001354. Epub 2021 May 28.
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Dapagliflozin in patients with heart failure and reduced ejection fraction.达格列净用于射血分数降低的心力衰竭患者。
Intern Emerg Med. 2020 Apr;15(3):515-517. doi: 10.1007/s11739-020-02297-0.
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Cost-effectiveness of Dapagliflozin for Treatment of Patients With Heart Failure With Reduced Ejection Fraction.达格列净治疗射血分数降低的心力衰竭患者的成本效益分析。
JAMA Cardiol. 2021 Aug 1;6(8):926-935. doi: 10.1001/jamacardio.2021.1437.
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Efficacy and Safety of Dapagliflozin in Men and Women With Heart Failure With Reduced Ejection Fraction: A Prespecified Analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure Trial.达格列净在射血分数降低的心力衰竭男性和女性患者中的疗效和安全性:达格列净和心力衰竭结局预防试验的预先指定分析。
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Efficacy and safety of sodium-glucose co-transporter 2 inhibition according to left ventricular ejection fraction in DAPA-HF.达格列净对射血分数降低的心力衰竭患者的疗效和安全性(DAPA-HF)。
Eur J Heart Fail. 2020 Jul;22(7):1247-1258. doi: 10.1002/ejhf.1867. Epub 2020 Jun 15.
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Topping Off the Pill Box: Dapagliflozin, Heart Failure, and Polypharmacy.
JACC Heart Fail. 2023 Oct;11(10):1394-1396. doi: 10.1016/j.jchf.2023.06.033. Epub 2023 Aug 9.
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Dapagliflozin pharmacokinetics is similar between patients with heart failure with reduced ejection fraction and patients with type 2 diabetes mellitus.达格列净的药代动力学在射血分数降低的心力衰竭患者和 2 型糖尿病患者之间相似。
Br J Clin Pharmacol. 2024 Feb;90(2):606-612. doi: 10.1111/bcp.15939. Epub 2023 Nov 20.
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NICE guidance on dapagliflozin for chronic heart failure with reduced ejection fraction.英国国家卫生与临床优化研究所关于达格列净用于射血分数降低的慢性心力衰竭的指南。
Lancet Diabetes Endocrinol. 2021 May;9(5):261-263. doi: 10.1016/S2213-8587(21)00072-3. Epub 2021 Mar 10.

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