Department of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Prades 226010, India.
Medical Physics Unit, IRCH, AIIMS, New Delhi 110029, India.
Phys Med. 2022 Sep;101:158-164. doi: 10.1016/j.ejmp.2022.08.012. Epub 2022 Aug 22.
Non-invasive DECT based characterization of renal stones using their effective atomic number (Z) and the electron density (ρe) in patients.
This paper aims to develop a method for in-vivo characterization of renal stone. Differentiation of renal stones in-vivo especially sub types of calcium stones have very important advantage for better judgement of treatment modality.
50 extracted renal stones were scanned ex-vivo using dual energy CT scanner. A method was developed to characterize these renal stones using effective atomic number and electron density obtained from dual energy CT data. The method and formulation developed in ex-vivo experiments was applied in in-vivo study of 50 randomly selected patients of renal stones who underwent dual energy CT scan.
The developed method was able to characterize Calcium Oxalate Monohydrate (COM) and the combination of COM and Calcium Oxalate Dihydrate (COD) stones non-invasively in patients with a sensitivity of 81% and 83%respectively. The method was also capable of differentiating Uric, Cystine and mixed stones with the sensitivity of 100, 100 and 85.71% respectively.
The developed dual energy CT based method was capable of differentiating sub types of calcium stones which is not differentiable on single energy or dual energy CT images.
利用有效原子序数（Z）和电子密度（ρe）对患者的肾结石进行基于 DECT 的无创特征描述。
本研究旨在开发一种对肾结石进行体内特征描述的方法。对体内肾结石（特别是钙结石亚型）进行区分，对于更好地判断治疗方式具有非常重要的优势。
对 50 颗离体肾结石进行双能 CT 扫描仪扫描。开发了一种使用双能 CT 数据得到的有效原子序数和电子密度对这些肾结石进行特征描述的方法。在对 50 名随机选择的肾结石患者进行双能 CT 扫描的体内研究中，应用了在离体实验中开发的方法和公式。
该方法能够对体内的一水合草酸钙（COM）和一水合草酸钙二水合物（COD）结石进行非侵入性特征描述，其敏感性分别为 81%和 83%。该方法还能够以 100%、100%和 85.71%的敏感性区分尿酸盐、胱氨酸和混合结石。
所开发的基于双能 CT 的方法能够区分单能或双能 CT 图像无法区分的钙结石亚型。
