NeuroOncology Laboratory, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
Eur J Pharmacol. 2022 Oct 15;933:175214. doi: 10.1016/j.ejphar.2022.175214. Epub 2022 Aug 23.
Opioids are one of the most effective anti-nociceptive agents used in patients with cancer pain or after serious surgery in most countries. The endogenous opioid system participates in pain perception, but recently its role in inflammation was determined. κ-opioid receptors (KOP receptors), a member of the opioid receptor family, are expressed in the central and peripheral nervous system as well as on the surface of different types of immune cells, e.g. T cells, B cells and monocytes. In this review, we focused on the involvement of KOP receptors in the inflammatory process and described their function in a number of conditions in which the immune system plays a key role (e.g. inflammatory bowel disease, arthritis, subarachnoid hemorrhage, vascular dysfunction) and inflammatory pain. We summed up the application of known KOP ligands in pathophysiology and we aimed to shed new light on KOP receptors as important elements during inflammation.
阿片类药物是大多数国家治疗癌症疼痛或严重手术后患者的最有效抗伤害感受药物之一。内源性阿片系统参与疼痛感知，但最近其在炎症中的作用已被确定。κ-阿片受体（KOP 受体）是阿片受体家族的成员，在中枢和外周神经系统以及不同类型的免疫细胞（如 T 细胞、B 细胞和单核细胞）的表面表达。在这篇综述中，我们重点关注 KOP 受体在炎症过程中的作用，并描述了它们在免疫系统起关键作用的多种情况下的功能（例如炎症性肠病、关节炎、蛛网膜下腔出血、血管功能障碍和炎症性疼痛）。我们总结了已知 KOP 配体在病理生理学中的应用，并旨在阐明 KOP 受体作为炎症过程中的重要因素。
