Tang Xiaoyuan, Zhao Yuxuan, Wang Xude, Ye Chongtao, Feng Baomin, Tang Chuan, Lu Xuan
College of Life Health, Dalian University, Dalian, 116622, People's Republic of China.
College of Medicine, Dalian University, Dalian, 116622, People's Republic of China.
Phytochemistry. 2022 Nov;203:113383. doi: 10.1016/j.phytochem.2022.113383. Epub 2022 Aug 23.
Seven undescribed polyketides with particular ortho-trisubstituted benzo[c]furan and benzo[c]oxepin spiro structures were isolated from Rhodiola tibetica endophytic fungus Alternaria sp. HJT-Y7. Structural elucidations of these compounds were determined mainly by NMR and HR-ESI-MS analysis. An assumed polyketide biosynthetic pathway of these isolates was proposed. Two undescribed compounds and four known compounds showed significant inhibitory effects on LPS-induced NO production in RAW 264.7 cells without cytotoxicity at their effective concentrations.
从西藏红景天内生真菌链格孢属HJT-Y7中分离出7种具有特殊邻位三取代苯并[c]呋喃和苯并[c]氧杂䓬螺环结构的未描述过的聚酮化合物。这些化合物的结构解析主要通过核磁共振（NMR）和高分辨电喷雾电离质谱（HR-ESI-MS）分析来确定。提出了这些分离物假定的聚酮生物合成途径。两种未描述过的化合物和四种已知化合物在有效浓度下对RAW 264.7细胞中脂多糖（LPS）诱导的一氧化氮（NO）生成具有显著抑制作用且无细胞毒性。
