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链格孢菌G和H：来自内生真菌HJT-Y7的苯并氧杂卓衍生物。

Alternarias G and H: Benzoxepine Derivatives from the Endophytic Fungus sp. HJT-Y7.

作者信息

Xiao Dongliang, Li Shuangcheng, Tang Xiaoyuan, Li Meng, Chen Gang, Zhang Xueni, Meng Churen, Li Jiaqi, Xu Jingyi, Feng Baomin, Lu Xuan

机构信息

College of Life and Health, Dalian University, Dalian 116622, People's Republic of China.

State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Beijing, 100700, People's Republic of China.

出版信息

ACS Omega. 2025 Jun 3;10(23):24973-24979. doi: 10.1021/acsomega.5c02528. eCollection 2025 Jun 17.

DOI:10.1021/acsomega.5c02528
PMID:40547658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12177614/
Abstract

Alternaria G (), a benzoxepine dimer with an unprecedented 6/7-7/6 tetracyclic skeleton, and a benzoxepine monomer, alternaria H (), were successfully isolated from the fungus Alternaria sp. HJT-Y7. Structural determination was accomplished through comprehensive spectroscopic data interpretation, supported by electronic circular dichroism calculations, and quantum-chemical NMR calculations with DP4+ probability analyses. Genomic exploration uncovered a candidate biosynthetic gene cluster ) putatively responsible for their assembly, from which a plausible biosynthetic route was proposed. Notably, significantly inhibited nitric oxide production in LPS-stimulated RAW 264.7 macrophages.

摘要

从链格孢属真菌HJT-Y7中成功分离出具有前所未有的6/7-7/6四环骨架的苯并氧杂卓二聚体链格孢菌素G（）和苯并氧杂卓单体链格孢菌素H（）。通过综合光谱数据解析，并辅以电子圆二色性计算以及采用DP4+概率分析的量子化学NMR计算完成了结构测定。基因组探索发现了一个可能负责其组装的候选生物合成基因簇，据此提出了一条合理的生物合成途径。值得注意的是，链格孢菌素G在脂多糖刺激的RAW 264.7巨噬细胞中显著抑制一氧化氮的产生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439d/12177614/7119812296b0/ao5c02528_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439d/12177614/de99a6afdc2b/ao5c02528_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439d/12177614/b4471f90abeb/ao5c02528_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439d/12177614/d691194c1818/ao5c02528_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439d/12177614/8daba8828c1b/ao5c02528_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439d/12177614/87aa39fc7e4f/ao5c02528_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439d/12177614/fde49d53efad/ao5c02528_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439d/12177614/7119812296b0/ao5c02528_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439d/12177614/de99a6afdc2b/ao5c02528_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439d/12177614/b4471f90abeb/ao5c02528_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439d/12177614/d691194c1818/ao5c02528_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439d/12177614/8daba8828c1b/ao5c02528_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439d/12177614/87aa39fc7e4f/ao5c02528_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439d/12177614/fde49d53efad/ao5c02528_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439d/12177614/7119812296b0/ao5c02528_0007.jpg

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