Department of Medicine, University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia; Department of Endocrinology, Austin Health, 145 Studley Road, Heidelberg, Victoria 3084, Australia; Australian Centre of Accelerating Diabetes Innovations (ACADI), University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia.
Department of Medicine, University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia; Australian Centre of Accelerating Diabetes Innovations (ACADI), University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia; School of Nursing, Midwifery and Paramedicine, University of the Sunshine Coast, 1 Moreton Parade, Petrie, Queensland 4502, Australia.
Diabetes Res Clin Pract. 2022 Sep;191:110042. doi: 10.1016/j.diabres.2022.110042. Epub 2022 Aug 23.
Type 1 diabetes is a significant, life-long condition which affects many people worldwide. One of the most feared causes of type 1 diabetes mortality, overnight mortality, often caused by the dead in bed syndrome, is largely underreported. A systematic literature search was undertaken to understand the frequency, risk factors, causes and impact that diabetes-related technologies have on overnight mortality, in this population.
MEDLINE (Ovid), Embase (Ovid) and Cochrane were searched to June 2021, using defined inclusion and exclusion criteria. Quality appraisal was undertaken.
Overall, 26 records met the inclusion criteria. Large-scale cohort studies examined data up to 2013, and there were no studies published after 2018. The proportion of deaths attributable to the dead in bed syndrome was between 2 and 5% of deaths in children, adolescents, and young adults, with a slight decrease in proportion of dead in bed syndrome since 1991.
Overnight mortality is occurring for people with type 1 diabetes, reported as recently as in 2018. Living alone, alcohol and illicit substances consistently appear as risk factors, and the impact of technology on overnight mortality is not fully understood, with more recent data, from larger cohort studies being required.
1 型糖尿病是一种严重的、终身性疾病，影响着全世界许多人。1 型糖尿病死亡的最可怕原因之一是夜间死亡，通常由卧床死亡综合征引起，而这种死亡在很大程度上报告不足。我们进行了系统的文献检索，以了解与糖尿病相关的技术对该人群的夜间死亡率的发生频率、风险因素、原因和影响。
使用明确的纳入和排除标准，对 MEDLINE（Ovid）、Embase（Ovid）和 Cochrane 进行了检索，检索时间截至 2021 年 6 月。进行了质量评估。
总体而言，有 26 份记录符合纳入标准。大规模队列研究检查了截至 2013 年的数据，自 2018 年以来没有发表过研究。儿童、青少年和年轻成人中归因于卧床死亡综合征的死亡比例为 2%至 5%，自 1991 年以来，卧床死亡综合征的比例略有下降。
自 2018 年以来，1 型糖尿病患者仍有夜间死亡报告。独居、饮酒和非法药物似乎一直是风险因素，而技术对夜间死亡率的影响尚不完全清楚，需要来自更大规模队列研究的最新数据。
