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Unmasking Schizophrenia: Synaptic Pruning in Adolescence Reveals a Latent Physiological Vulnerability in Prefrontal Recurrent Networks.

作者信息

Chafee Matthew V, Averbeck Bruno B

机构信息

Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota.

Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.

出版信息

Biol Psychiatry. 2022 Sep 15;92(6):436-439. doi: 10.1016/j.biopsych.2022.06.023.

DOI:10.1016/j.biopsych.2022.06.023
PMID:36008035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9870034/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbdc/9870034/75bdaae4adc4/nihms-1862728-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbdc/9870034/75bdaae4adc4/nihms-1862728-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbdc/9870034/75bdaae4adc4/nihms-1862728-f0001.jpg

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本文引用的文献

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Integrating the Neurodevelopmental and Dopamine Hypotheses of Schizophrenia and the Role of Cortical Excitation-Inhibition Balance.整合精神分裂症的神经发育和多巴胺假说以及皮质兴奋-抑制平衡的作用。
Biol Psychiatry. 2022 Sep 15;92(6):501-513. doi: 10.1016/j.biopsych.2022.06.017. Epub 2022 Jun 22.
2
Etiopathogenic Models of Psychosis Spectrum Illnesses Must Resolve Four Key Features.精神病谱系疾病的病因发病模型必须解决四个关键特征。
Biol Psychiatry. 2022 Sep 15;92(6):514-522. doi: 10.1016/j.biopsych.2022.06.024. Epub 2022 Jun 25.
3
Impact of Maternal Immune Activation on Nonhuman Primate Prefrontal Cortex Development: Insights for Schizophrenia.母体免疫激活对非人灵长类前额叶皮层发育的影响：精神分裂症的启示。
Biol Psychiatry. 2022 Sep 15;92(6):460-469. doi: 10.1016/j.biopsych.2022.04.004. Epub 2022 Apr 21.
4
The Neuroepigenome: Implications of Chemical and Physical Modifications of Genomic DNA in Schizophrenia.神经表观基因组：精神分裂症中基因组 DNA 的化学和物理修饰的影响。
Biol Psychiatry. 2022 Sep 15;92(6):443-449. doi: 10.1016/j.biopsych.2022.04.018. Epub 2022 May 10.
5
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Cognitive Dysfunction and Prefrontal Cortical Circuit Alterations in Schizophrenia: Developmental Trajectories.精神分裂症的认知功能障碍与前额叶皮层回路改变：发展轨迹。
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Thalamocortical Development: A Neurodevelopmental Framework for Schizophrenia.丘脑皮质发育：精神分裂症的神经发育框架。
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Biol Psychiatry. 2022 Sep 15;92(6):480-490. doi: 10.1016/j.biopsych.2022.02.003. Epub 2022 Feb 12.
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Patient-Derived In Vitro Models of Microglial Function and Synaptic Engulfment in Schizophrenia.精神分裂症中微胶质细胞功能和突触吞噬的患者来源体外模型。
Biol Psychiatry. 2022 Sep 15;92(6):470-479. doi: 10.1016/j.biopsych.2022.01.004. Epub 2022 Jan 19.
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A Critical Perspective on the Synaptic Pruning Hypothesis of Schizophrenia Pathogenesis.对精神分裂症发病机制的突触修剪假说的批判性观点。
Biol Psychiatry. 2022 Sep 15;92(6):440-442. doi: 10.1016/j.biopsych.2021.12.014. Epub 2022 Jan 2.