Hyperlipidemia and monoclonal gammapathy.

A combination of hyperlipoproteinemia and monoclonal gammapathy was described in 4 women and one man (mean age 53.4 years). Monoclonal IgG1 was demonstrated in the serum of all the patients, four times with the lambda type light chains and once with the kappa type. In the patients with monoclonal IgG-lambda, IIb type hyperlipoproteinemia according to Fredrickson's classification was established in three cases and type V in one case. Type IV hyperlipoproteinemia was found in the woman patient with IgG-kappa gammapathy.