Department of Immunology, School of Basic Medicine, Hebei Medical University, 361 Zhongshan East Rd., Shijiazhuang 050017, China.
The First Hospital of Hebei Medical University, Shijiazhuang 050030, China.
Biomolecules. 2022 Jul 28;12(8):1042. doi: 10.3390/biom12081042.
As the most abundant internal mRNA modification in eukaryotic cells, -methyladenosine (mA) has emerged as an important regulator of gene expression and has a profound impact on cancer initiation and progression. mRNA mA modification is regulated by mA methyltransferases, demethylases and reader proteins to fine tune gene expression at the post-transcriptional level. The most well-studied mA methyltransferase, METTL3, plays critical roles in regulating gene expression and affecting the outcome of various cancers. In this review, we discuss the multifaceted roles of METTL3 in regulating specific molecular signaling pathways in different types of cancers and the recent progress on how METTL3 impacts the tumor immune microenvironment. Finally, we discuss future directions and the potential for therapeutic targeting of METTL3 in cancer treatment.
作为真核细胞中最丰富的内部 mRNA 修饰，N6-甲基腺苷（m6A）已成为基因表达的重要调节剂，对癌症的发生和发展有深远影响。mRNA m6A 修饰受 m6A 甲基转移酶、去甲基化酶和读码蛋白的调控，以在转录后水平精细调节基因表达。研究最充分的 m6A 甲基转移酶 METTL3 在调节基因表达和影响各种癌症的结果方面发挥着关键作用。在这篇综述中，我们讨论了 METTL3 在调节不同类型癌症中特定分子信号通路方面的多方面作用，以及 METTL3 如何影响肿瘤免疫微环境的最新进展。最后，我们讨论了未来的方向和针对癌症治疗中 METTL3 的治疗靶向的潜力。
