Secretory Physiology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Biomolecules. 2022 Aug 20;12(8):1152. doi: 10.3390/biom12081152.
ER-PM junctions are membrane contact sites formed by the endoplasmic reticulum (ER) and plasma membrane (PM) in close apposition together. The formation and stability of these junctions are dependent on constitutive and dynamic enrichment of proteins, which either contribute to junctional stability or modulate the lipid levels of both ER and plasma membranes. The ER-PM junctions have come under much scrutiny recently as they serve as hubs for assembling the Ca signaling complexes. This review summarizes: (1) key findings that underlie the abilities of STIM proteins to accumulate in ER-PM junctions; (2) the modulation of Orai/STIM complexes by other components found within the same junction; and (3) how Orai1 channel activation is coordinated and coupled with downstream signaling pathways.
ER-PM 连接点是内质网 (ER) 和质膜 (PM) 紧密并置形成的膜接触位点。这些连接点的形成和稳定性取决于蛋白质的组成和动态富集，这些蛋白质要么有助于连接点的稳定性，要么调节 ER 和质膜的脂质水平。ER-PM 连接点最近受到了广泛关注，因为它们是组装 Ca 信号复合物的中心。这篇综述总结了：（1）STIM 蛋白在内质网-质膜连接点积累的能力的关键发现；（2）同一连接点内其他成分对 Orai/STIM 复合物的调节；（3）Orai1 通道的激活如何与下游信号通路协调和偶联。
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