Beauchet Olivier, Matskiv Jacqueline, Rolland Yves, Schott Anne-Marie, Allali Gilles
Departments of Medicine and Geriatrics, University of Montreal, Montreal, QC H3W 1W5, Canada.
Research Centre of the Geriatric University Institute of Montreal, Montreal, QC H3W 1W5, Canada.
Brain Sci. 2022 Jul 31;12(8):1021. doi: 10.3390/brainsci12081021.
Cognitive and motor impairments are risk factors of major neurocognitive disorders (MNCD). Inability to name the date and use of a walking aid and/or history of falls are two items which are surrogate measures of cognitive and motor impairments. This study aims to examine the association of inability to name the date (i.e., cognitive impairment), use of a walking aid and/or history of falls (i.e., motor impairment) and their combination with incident MNCD in community-dwelling older adults.
A total of 709 participants (mean age 79.8 ± 3.7; 100% female) of the EPIDémiologie de l'OStéoporose (EPIDOS) study recruited in Toulouse (France) were selected for this study. EPIDOS is an observational population-based cohort study with a 7-year follow-up period for Toulouse participants. Inability to name the date and use of a walking aid and/or history of falls were collected at baseline. Incident MNCD and their type (i.e., Alzheimer's disease (AD) and non-AD) were diagnosed at the end of the 7-year follow-up.
Overall incidence of MNCD was 29.1%. Cox regressions revealed that inability to name the date and its combination with use of a walking aid and/or history of falls was associated with a significant increased incidence of MNCD (hazard ratio (HR) = 1.10 with = 0.003 and HR = 1.81 with = 0.011, respectively) and AD (HR =1.13 with = 0.003 and HR = 2.80 with = 0.016, respectively).
Increased incident MNCD was reported when inability to name the date and use of a walking aid and/or history of falls were combined, suggesting that this combination of items may be used for risk screening of MNCD in the older population, especially for incident AD.
认知和运动障碍是主要神经认知障碍（MNCD）的危险因素。无法说出日期、使用助行器和/或跌倒史是认知和运动障碍的两项替代指标。本研究旨在探讨社区居住的老年人中无法说出日期（即认知障碍）、使用助行器和/或跌倒史（即运动障碍）及其组合与MNCD发病之间的关联。
本研究选取了在法国图卢兹招募的骨质疏松症流行病学（EPIDOS）研究中的709名参与者（平均年龄79.8±3.7岁；100%为女性）。EPIDOS是一项基于人群的观察性队列研究，对图卢兹的参与者进行了7年的随访。在基线时收集无法说出日期、使用助行器和/或跌倒史的信息。在7年随访结束时诊断出MNCD及其类型（即阿尔茨海默病（AD）和非AD）。
MNCD的总体发病率为29.1%。Cox回归显示，无法说出日期及其与使用助行器和/或跌倒史的组合与MNCD发病率显著增加相关（风险比（HR）分别为1.10，P = 0.003；HR为1.81，P = 0.011），与AD发病率也显著增加相关（HR分别为1.13，P = 0.003；HR为2.80，P = 0.016）。
当无法说出日期与使用助行器和/或跌倒史同时存在时，MNCD的发病风险增加，这表明这些指标的组合可用于老年人群中MNCD的风险筛查，尤其是对于AD的发病风险筛查。
