Department of Medicine, Division of Geriatric Medicine, Sir Mortimer B. Davis Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada.
Dr. Joseph Kaufmann Chair in Geriatric Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Age Ageing. 2021 May 5;50(3):969-973. doi: 10.1093/ageing/afaa235.
The co-occurrence of slow walking speed and subjective cognitive complaint (SCC) in non-demented individuals defines motoric cognitive risk syndrome (MCR), which is a pre-dementia stage. There is no information on the association between MCR and incident dementia in Québec's older population.
The study aims to examine the association of MCR and its individual components (i.e. SCC and slow walking speed) with incident dementia in community-dwelling older adults living in the province of Québec (Canada).
Québec older people population-based observational cohort study with 3 years of follow-up.
Community dwellings.
A subset of participants (n = 1,098) in 'Nutrition as a determinant of successful aging: The Québec longitudinal study' (NuAge).
At baseline, participants with MCR were identified. Incident dementia was measured at annual follow-up visits using the Modified Mini-Mental State (≤79/100) test and Instrumental Activity Daily Living scale (≤6/8) score values.
The prevalence of MCR was 4.2% at baseline and the overall incidence of dementia was 3.6%. MCR (Hazard Ratio (HR) = 5.18, with 95% confidence interval (CI) = [2.43-11.03] and P ≤ 0.001) and SCC alone (HR = 2.54, with 95% CI = [1.33-4.85] and P = 0.005) were associated with incident dementia, but slow walking speed was not (HR = 0.81, with 95%CI = [0.25-2.63] and P = 0.736).
MCR and SCC are associated with incident dementia in NuAge study participants.
在非痴呆个体中，缓慢的步行速度和主观认知主诉（SCC）同时出现定义了运动认知风险综合征（MCR），这是一种痴呆前阶段。在魁北克省的老年人群中，尚无关于 MCR 与痴呆发生之间关联的信息。
本研究旨在检查 MCR 及其个体成分（即 SCC 和缓慢的步行速度）与居住在魁北克省（加拿大）的社区居住的老年成年人发生痴呆的相关性。
魁北克老年人基于人群的观察性队列研究，随访 3 年。
社区住宅。
“营养作为成功老龄化的决定因素：魁北克纵向研究”（NuAge）的参与者子集（n=1098）。
在基线时，确定了具有 MCR 的参与者。在年度随访中，使用改良的简易精神状态检查（≤79/100）测试和工具性日常生活活动量表（≤6/8）评分值来测量痴呆的发生。
MCR 的基线患病率为 4.2%，痴呆的总发生率为 3.6%。MCR（危险比（HR）=5.18，95%置信区间（CI）=[2.43-11.03]，P≤0.001）和单独的 SCC（HR=2.54，95%CI=[1.33-4.85]，P=0.005）与痴呆的发生相关，但步行速度缓慢与痴呆的发生无关（HR=0.81，95%CI=[0.25-2.63]，P=0.736）。
在 NuAge 研究参与者中，MCR 和 SCC 与痴呆的发生相关。
