Muto S, Asano Y, Hosoda S, Shionoya S, Miura Y, Urabe A, Takaku F
Nephron. 1987;46(1):34-6. doi: 10.1159/000184292.
This report describes the case of a 50-year-old male with end-stage renal failure accompanied with congenital heart disease and polycythemia. After he had received continuous ambulatory peritoneal dialysis for 1 year, he still remained polycythemic and his serum erythropoietin titer, assayed using fetal mouse liver cells, was markedly increased. An inhibitory effect on erythropoiesis was not detected by this method. Bone marrow examination showed erythroid hyperplasia. These phenomena could be explained by an overproduction of erythropoietin by the remnant kidneys or extrarenal organs, such as the liver, in response to persisting hypoxia. The patient's bone marrow was still responsive to erythropoietin.
本报告描述了一名50岁男性患者的病例，该患者患有终末期肾衰竭，并伴有先天性心脏病和红细胞增多症。在接受持续性非卧床腹膜透析1年后，他仍存在红细胞增多，且使用胎鼠肝细胞检测的血清促红细胞生成素滴度显著升高。用该方法未检测到对红细胞生成的抑制作用。骨髓检查显示红系增生。这些现象可以解释为残余肾脏或肝等肾外器官因持续缺氧而过度产生促红细胞生成素。患者的骨髓对促红细胞生成素仍有反应。
