Kuropka Piotr, Leśków Anna, Małolepsza-Jarmołowska Katarzyna, Dobrzyński Maciej, Tarnowska Małgorzata, Majda Jacek, Janeczek Maciej, Żybura-Wszoła Katarzyna, Gamian Andrzej
Department of Biostructure and Animal Physiology, Wrocław University of Environmental and Life Sciences, Norwida 31, 50-375 Wrocław, Poland.
Department of Basic Sciences, Wroclaw Medical University, Chałubińskiego 4, 50-368 Wrocław, Poland.
Animals (Basel). 2022 Aug 17;12(16):2110. doi: 10.3390/ani12162110.
This study aimed to evaluate the impact of single and triple administration of levamisole on the dynamics of hematological parameters during experimental pleuritis. The experiment was performed on female Buffalo rats. Rats were randomly assigned to two equal groups that received 1 and 3 doses of levamisole every 2, 24 and 48 h, respectively. Following the experiment, blood samples for the measurement of hematological parameters were collected. The study group receiving three doses of levamisole observed a significant reduction of red blood cell count at 48 h post administration and an increase in mean corpuscular volume compared to the control inflammation group. The administration of a single dose of levamisole results in a significant increase in hematocrit at 72 h, an increase in white blood cell count at 24 h and 72 h, and an increase in neutrophil count at 72 h compared to the control inflammation group. Administration of a single and triple dose of levamisole showed statistically significant modification of some hematological parameters and thus modulates the inflammatory process. In the lungs, this results in a reduction in leukocyte infiltrations around the bronchi and blood vessels.
本研究旨在评估左旋咪唑单次和三次给药对实验性胸膜炎期间血液学参数动态变化的影响。实验选用雌性水牛大鼠进行。大鼠被随机分为两组，每组数量相等，分别每2小时、24小时和48小时接受1剂和3剂左旋咪唑。实验结束后，采集血液样本以测量血液学参数。与对照炎症组相比，接受三剂左旋咪唑的研究组在给药后48小时红细胞计数显著降低，平均红细胞体积增加。与对照炎症组相比，单次给药左旋咪唑导致在72小时时血细胞比容显著增加，在24小时和72小时时白细胞计数增加，在72小时时中性粒细胞计数增加。单次和三次给药左旋咪唑均显示出一些血液学参数有统计学意义的改变，从而调节了炎症过程。在肺部，这导致支气管和血管周围白细胞浸润减少。
