Całkosiński Ireneusz, Majda Jacek, Terlecki Grzegorz, Gostomska-Pampuch Kinga, Małolepsza-Jarmołowska Katarzyna, Sobolewska Sylwia, Całkosińska Aleksandra, Kumala Aleksandra, Gamian Andrzej
Independent Laboratory of Neurotoxicology and Environmental Diagnostics, Wroclaw Medical University, Bartla 5, 51-618, Wroclaw, Poland.
Department of Laboratory Diagnostics, 4th Military Hospital, Weigla 5, 50-981, Wroclaw, Poland.
Inflammation. 2016 Jun;39(3):1076-89. doi: 10.1007/s10753-016-0339-x.
A significant role is played in inflammation by the liver, which, stimulated by inflammatory mediators, synthetizes plasma proteins with various dynamics. The purpose of these studies is to generate a detailed dynamic analysis of changes to concentrations of plasma and serum protein fractions and selected acute-phase proteins as well as nonspecific biochemical indices during the course of an induced pleurisy. The studies were conducted on female inbred Buffalo rats, which were divided into two groups: a control group (C) and an experimental group (IP) in which pleurisy was induced. In the IP group, significant changes in biochemical indices were observed between the 48th and 96th hours of pleurisy. A reduction of albumin, transferrin, urea, and creatinine concentrations was observed, while concentrations of the complement components C3 and C4, haptoglobin, and fibrinogen increased. An early increase of IL-1 was observed, while increases of IL-6 and TNF were noted in the later period. The maximum intensity of the processes described above occurred between the 72nd and 96th hours of pleurisy.
肝脏在炎症过程中发挥着重要作用，它在炎症介质的刺激下，以不同的动态合成血浆蛋白。这些研究的目的是对诱导性胸膜炎过程中血浆和血清蛋白组分、选定的急性期蛋白以及非特异性生化指标浓度的变化进行详细的动态分析。研究在雌性近交布法罗大鼠身上进行，这些大鼠被分为两组：对照组（C）和诱导胸膜炎的实验组（IP）。在IP组中，在胸膜炎的第48小时至96小时之间观察到生化指标有显著变化。观察到白蛋白、转铁蛋白、尿素和肌酐浓度降低，而补体成分C3和C4、触珠蛋白和纤维蛋白原的浓度增加。观察到IL-1早期升高，而IL-6和TNF在后期升高。上述过程的最大强度出现在胸膜炎的第72小时至96小时之间。
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