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失踪受试者的药理学史:用于辅助骨骼遗骸研究的校正因子视角

Pharmacological History of Missing Subjects: Perspective of a Correction Factor to Aid in the Study of Bone Remains.

作者信息

Cecannecchia Camilla, Baldari Benedetta, Cioffi Andrea

机构信息

Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, 00161 Rome, Italy.

出版信息

Biology (Basel). 2022 Jul 27;11(8):1128. doi: 10.3390/biology11081128.

Abstract

In forensic anthropology, bone mineral density and the estimation of the dating of fractures based on the degree of progress of healing processes are important parameters of study on bone remains. With our article we aim, on the one hand, to highlight the importance that these parameters have in the reconstruction of the biological profile of the subject, as well as the time and the cause of death; on the other hand, we aim to limit their variability according to the medical substances and/or abuse assumed during life by the subject. The aim of this article is to encourage the introduction of the pharmacological history of missing persons as a new correction factor for the study of bone remains, possibly based on new scientific studies that allow us to establish with greater specificity the effect that certain pharmacological therapies produce on bone mass and the speed of remodeling.

摘要

在法医人类学中,骨矿物质密度以及基于愈合过程进展程度对骨折日期的估计是骨骼遗骸研究的重要参数。通过我们的文章,一方面,我们旨在强调这些参数在重建个体生物学特征以及死亡时间和原因方面的重要性;另一方面,我们旨在根据个体生前假定使用的药物和/或滥用情况来限制这些参数的变异性。本文的目的是鼓励引入失踪人员的用药史,作为研究骨骼遗骸的一个新的校正因素,这可能基于新的科学研究,使我们能够更具体地确定某些药物治疗对骨量和重塑速度产生的影响。

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本文引用的文献

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On age-dependent bone remodeling.关于与年龄相关的骨骼重塑。
J Biomech. 2020 Apr 16;103:109701. doi: 10.1016/j.jbiomech.2020.109701. Epub 2020 Feb 26.
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Drugs Causing Bone Loss.导致骨质流失的药物。
Handb Exp Pharmacol. 2020;262:475-497. doi: 10.1007/164_2019_340.
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Differentiating trauma from taphonomic alterations.区分创伤与尸骸变化。
Forensic Sci Int. 2019 Sep;302:109893. doi: 10.1016/j.forsciint.2019.109893. Epub 2019 Jul 27.

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