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阿拉伯婴儿中婴儿配方奶粉和五岁以下儿童食品铝暴露的儿科健康风险评估:黎巴嫩的经验

Pediatric Health Risk Assessment for Exposure to Aluminum from Infant Formulas and Children under the Age of Five's Food Products among Arab Infants: Experience from Lebanon.

作者信息

Ibrahim Carla, Kammouni Zeinab, Barake Maryam, Kassir Mounir, Al-Jawaldeh Ayoub, Matta Joseph, Sacre Yonna, Hanna-Wakim Lara, Haddad Joyce, Hoteit Maha

机构信息

Doctoral School of Sciences and Technology (DSST), Lebanese University, Hadath 6573, Lebanon.

Faculty of Public Health, Section 1, Lebanese University, Beirut 6573, Lebanon.

出版信息

Foods. 2022 Aug 19;11(16):2503. doi: 10.3390/foods11162503.

Abstract

Chronic dietary aluminum (Al) exposure can have various negative effects on health. The aim of our study is to (1) assess the contamination level of Al in infant formulas (n = 41) and baby food products (n = 76) available in the Lebanese market, and to (2) evaluate the margin of exposure of Al through the consumption of these foods among children under the age of five in Lebanon. Flame atomic absorption spectrometry (FAAS) was used to evaluate all of the samples. Al levels in all tested children’s food items were below the limit of detection. The highest Al level was detected in cornflakes (0.361 ± 0.049 mg/kg) and pureed foods (0.362 ± 0.079 mg/kg). Among infants aged 0−23 months, the average Al exposure due to the daily intake of infant formulas and baby foods was 0.01 and 0.0104 mg/kg BW/day for males and females, respectively. Babies aged 8−10 and 3−5 months had the highest and lowest levels of Al exposure, respectively. Additionally, the toxicological contribution of Al exposure determined for several age groups to a provisional tolerated weekly intake (PTWI) set by JECFA was  <6% and  <7% for males and females, respectively. The total Al exposure through the consumption of infant formulas and complementary foods among all ages in both males and females was below the values of weekly tolerable intakes (2 mg/kg/BW/W) set by JECFA. However, the values of hazard quotient (HQ) exceeded 1 in both male and female Lebanese infants. As a result, the risk of infants being exposed to Al in baby foods needs to be continuously considered.

摘要

长期膳食铝暴露会对健康产生多种负面影响。我们研究的目的是:(1)评估黎巴嫩市场上婴儿配方奶粉(n = 41)和婴儿食品(n = 76)中的铝污染水平,以及(2)评估黎巴嫩五岁以下儿童通过食用这些食品摄入铝的暴露边际。采用火焰原子吸收光谱法(FAAS)对所有样品进行评估。所有测试的儿童食品中的铝含量均低于检测限。玉米片(0.361±0.049毫克/千克)和泥状食品(0.362±0.079毫克/千克)中的铝含量最高。在0至23个月大的婴儿中,男性和女性因每日摄入婴儿配方奶粉和婴儿食品导致的平均铝暴露量分别为0.01和0.0104毫克/千克体重/天。8至10个月和3至5个月大的婴儿铝暴露水平分别最高和最低。此外,针对几个年龄组确定的铝暴露对食品添加剂联合专家委员会设定的暂定每周耐受摄入量(PTWI)的毒理学贡献,男性和女性分别<6%和<7%。男性和女性各年龄段通过食用婴儿配方奶粉和辅食摄入的总铝暴露量均低于食品添加剂联合专家委员会设定的每周耐受摄入量值(2毫克/千克/体重/周)。然而,黎巴嫩男、女婴儿的危害商数(HQ)值均超过1。因此,需要持续关注婴儿食品中铝暴露的风险。

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