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Pediatric Health Risk Assessment for Exposure to Aluminum from Infant Formulas and Children under the Age of Five's Food Products among Arab Infants: Experience from Lebanon.阿拉伯婴儿中婴儿配方奶粉和五岁以下儿童食品铝暴露的儿科健康风险评估:黎巴嫩的经验
Foods. 2022 Aug 19;11(16):2503. doi: 10.3390/foods11162503.
2
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本文引用的文献

1
Safety of aluminium from dietary intake - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC).膳食摄入铝的安全性——食品添加剂、香料、加工助剂及食品接触材料(AFC)小组的科学意见
EFSA J. 2008 Jul 15;6(7):754. doi: 10.2903/j.efsa.2008.754. eCollection 2008 Jul.
2
Correlates of Sub-Optimal Feeding Practices among under-5 Children amid Escalating Crises in Lebanon: A National Representative Cross-Sectional Study.黎巴嫩危机不断升级背景下5岁以下儿童喂养方式欠佳的相关因素:一项全国代表性横断面研究
Children (Basel). 2022 Jun 1;9(6):817. doi: 10.3390/children9060817.
3
Assessment of Aluminum via Baby Foods Consumption in Turkey: Estimated Early-Life Dietary Exposure and Target Hazard Quotient.通过婴儿食品摄入评估土耳其的铝含量:估计早期生活饮食暴露和目标危害系数。
Biol Trace Elem Res. 2022 Aug;200(8):3892-3901. doi: 10.1007/s12011-021-02961-2. Epub 2021 Oct 18.
4
Aluminum environmental pollution: the silent killer.铝的环境污染:无声的杀手。
Environ Sci Pollut Res Int. 2021 Sep;28(33):44587-44597. doi: 10.1007/s11356-021-14700-0. Epub 2021 Jul 1.
5
Determination of Aluminum, Chromium, and Barium Concentrations in Infant Formula Marketed in Lebanon.测定黎巴嫩市场上婴儿配方食品中的铝、铬和钡浓度。
J Food Prot. 2020 Oct 1;83(10):1738-1744. doi: 10.4315/JFP-20-003.
6
Aluminum exposure from food in the population of Lebanon.黎巴嫩人群通过食物摄入铝的情况。
Toxicol Rep. 2020 Aug 22;7:1025-1031. doi: 10.1016/j.toxrep.2020.08.018. eCollection 2020.
7
Public Health and Paediatric Risk Assessment of Aluminium, Arsenic and Mercury in Infant Formulas Marketed in Nigeria.尼日利亚市场上婴儿配方奶粉中铝、砷和汞的公共卫生与儿科风险评估
Sultan Qaboos Univ Med J. 2020 Feb;20(1):e63-e70. doi: 10.18295/squmj.2020.20.01.009. Epub 2020 Mar 9.
8
French infant total diet study: Exposure to selected trace elements and associated health risks.法国婴幼儿全面膳食研究:暴露于选定微量元素和相关健康风险。
Food Chem Toxicol. 2018 Oct;120:625-633. doi: 10.1016/j.fct.2018.07.062. Epub 2018 Aug 2.
9
Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer's disease and age-related neurodegeneration.低水平的铝会导致与阿尔茨海默病和年龄相关的神经退行性变相关的行为和形态学变化。
Neurotoxicology. 2016 Jan;52:222-9. doi: 10.1016/j.neuro.2015.12.002. Epub 2015 Dec 12.
10
Safety assessment of essential and toxic metals in infant formulas.婴儿配方奶粉中必需金属和有毒金属的安全性评估。
Turk J Pediatr. 2014 Jul-Aug;56(4):385-91.

阿拉伯婴儿中婴儿配方奶粉和五岁以下儿童食品铝暴露的儿科健康风险评估:黎巴嫩的经验

Pediatric Health Risk Assessment for Exposure to Aluminum from Infant Formulas and Children under the Age of Five's Food Products among Arab Infants: Experience from Lebanon.

作者信息

Ibrahim Carla, Kammouni Zeinab, Barake Maryam, Kassir Mounir, Al-Jawaldeh Ayoub, Matta Joseph, Sacre Yonna, Hanna-Wakim Lara, Haddad Joyce, Hoteit Maha

机构信息

Doctoral School of Sciences and Technology (DSST), Lebanese University, Hadath 6573, Lebanon.

Faculty of Public Health, Section 1, Lebanese University, Beirut 6573, Lebanon.

出版信息

Foods. 2022 Aug 19;11(16):2503. doi: 10.3390/foods11162503.

DOI:10.3390/foods11162503
PMID:36010503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9407326/
Abstract

Chronic dietary aluminum (Al) exposure can have various negative effects on health. The aim of our study is to (1) assess the contamination level of Al in infant formulas (n = 41) and baby food products (n = 76) available in the Lebanese market, and to (2) evaluate the margin of exposure of Al through the consumption of these foods among children under the age of five in Lebanon. Flame atomic absorption spectrometry (FAAS) was used to evaluate all of the samples. Al levels in all tested children’s food items were below the limit of detection. The highest Al level was detected in cornflakes (0.361 ± 0.049 mg/kg) and pureed foods (0.362 ± 0.079 mg/kg). Among infants aged 0−23 months, the average Al exposure due to the daily intake of infant formulas and baby foods was 0.01 and 0.0104 mg/kg BW/day for males and females, respectively. Babies aged 8−10 and 3−5 months had the highest and lowest levels of Al exposure, respectively. Additionally, the toxicological contribution of Al exposure determined for several age groups to a provisional tolerated weekly intake (PTWI) set by JECFA was  <6% and  <7% for males and females, respectively. The total Al exposure through the consumption of infant formulas and complementary foods among all ages in both males and females was below the values of weekly tolerable intakes (2 mg/kg/BW/W) set by JECFA. However, the values of hazard quotient (HQ) exceeded 1 in both male and female Lebanese infants. As a result, the risk of infants being exposed to Al in baby foods needs to be continuously considered.

摘要

长期膳食铝暴露会对健康产生多种负面影响。我们研究的目的是:(1)评估黎巴嫩市场上婴儿配方奶粉(n = 41)和婴儿食品(n = 76)中的铝污染水平,以及(2)评估黎巴嫩五岁以下儿童通过食用这些食品摄入铝的暴露边际。采用火焰原子吸收光谱法(FAAS)对所有样品进行评估。所有测试的儿童食品中的铝含量均低于检测限。玉米片(0.361±0.049毫克/千克)和泥状食品(0.362±0.079毫克/千克)中的铝含量最高。在0至23个月大的婴儿中,男性和女性因每日摄入婴儿配方奶粉和婴儿食品导致的平均铝暴露量分别为0.01和0.0104毫克/千克体重/天。8至10个月和3至5个月大的婴儿铝暴露水平分别最高和最低。此外,针对几个年龄组确定的铝暴露对食品添加剂联合专家委员会设定的暂定每周耐受摄入量(PTWI)的毒理学贡献,男性和女性分别<6%和<7%。男性和女性各年龄段通过食用婴儿配方奶粉和辅食摄入的总铝暴露量均低于食品添加剂联合专家委员会设定的每周耐受摄入量值(2毫克/千克/体重/周)。然而,黎巴嫩男、女婴儿的危害商数(HQ)值均超过1。因此,需要持续关注婴儿食品中铝暴露的风险。