Palummeri E, Girasole G, Davoli L, Bergonzani M, Pioli G, Meola P, Butturini L, Barbagallo M, Ciotti G, Pedrazzoni M
Minerva Med. 1987 Jun 30;78(12):809-14.
In order to evaluate the age-related changes of the bone mineral content (BMC), 281 clinically healthy women (20-80 year old) underwent single photon abosorptiometry (SPA) on the distal third of the radius (where there is a prevalence of cortical bone); 161 subjects of this group were examined also by dual photon absorptiometry (DPA) of the lumbar tract of the spine (L2-L4) (trabecular bone). The relationship of trabecular BMC with age is described by a cubic polynomial regression (r = 0.46; p less than 0.0001) that shows an increase in BMC until 31 years of age followed by a decrease with a minimum at the age of 78; afterwards trabecular BMC adds an apparent increase. No increase in the rate of trabecular BMC loss was seen after the menopause. A positive correlation was found between body weight and vertebral BMC. The behaviour of cortical BMC with age is described by a quadratic regression (r = 0.42; p less than 0.0001) that shows an increase until 32 years of age followed by a decrease. Cortical BMC shows a significant decrease after menopause. No correlation was found between body weight and cortical BMC. These findings underline the different behaviour of trabecular and cortical bone tissue with age; in addition, the relation between trabecular (but not cortical) BMC and body weight argues for an important role of biomechanical factors in the local modulation of bone mass.
为了评估骨矿物质含量（BMC）与年龄相关的变化，281名临床健康女性（20 - 80岁）接受了桡骨远端三分之一处（此处以皮质骨为主）的单光子吸收测定法（SPA）；该组中的161名受试者还接受了脊柱腰段（L2 - L4）（松质骨）的双光子吸收测定法（DPA）检查。松质骨BMC与年龄的关系通过三次多项式回归描述（r = 0.46；p小于0.0001），结果显示BMC在31岁之前增加，之后下降，在78岁时达到最低；此后松质骨BMC又有明显增加。绝经后未观察到松质骨BMC丢失率增加。体重与椎体BMC之间存在正相关。皮质骨BMC与年龄的关系通过二次回归描述（r = 0.42；p小于0.0001），结果显示在32岁之前增加，之后下降。绝经后皮质骨BMC显著下降。体重与皮质骨BMC之间未发现相关性。这些发现强调了松质骨和皮质骨组织随年龄变化的不同行为；此外，松质骨（而非皮质骨）BMC与体重之间的关系表明生物力学因素在局部骨量调节中起重要作用。
