Pasqualetti P, Casale R, Colantonio D, Natali G
Minerva Med. 1987 Jul 15;78(13):907-10.
A case of simultaneous evidence of plasma cell leukaemia and multiple myeloma is reported. Plasma cell leukaemia doesn't represent an evolution of multiple myeloma, but a primitive disease, because the two forms of plasma cell dyscrasia arose from two different neoplastic plasma cell populations. In fact, leukaemic plasma cell produced IgA and were PAS-positive, while myelomatous plasma cells produced IgG and were PAS-negative. From this case, some hypothesis on simultaneous development of the two types of plasma cell neoplasias are discussed.
报告了一例同时存在浆细胞白血病和多发性骨髓瘤证据的病例。浆细胞白血病并非多发性骨髓瘤的进展,而是一种原发性疾病,因为这两种浆细胞发育异常形式源自两个不同的肿瘤性浆细胞群体。事实上,白血病性浆细胞产生IgA且PAS染色呈阳性,而骨髓瘤性浆细胞产生IgG且PAS染色呈阴性。基于此病例,讨论了关于这两种类型浆细胞肿瘤同时发生的一些假说。