Kreutner A K, del Bene V E, Delamar D, Huguley V, Harmon P M, Mitchell K S
Obstet Gynecol. 1978 Sep;52(3):279-84.
The effect of an 8-hour, 3-dose perioperative regimen of cefazolin or placebo was evaluated in 97 patients. Postoperative morbidity occurred in 13 patients (27.1%) in the cefazolin group and in 17 patients (34.7%) who received placebo. The clinical sites of infection were similar in both groups except that wound infections (2) and sepsis (2) were found only in patients receiving placebo. Aerobic organisms diminished and anaerobes increased in patients who received antibiotics. Aerobic isolates were essentially unchanged and fewer anaerobes were recovered from patients given placebo. Antibiotic levels observed at cesarean section were in the therapeutic range. The only risk factor which correlated with morbidity was the presence of ruptured membranes. This short course, single drug regimen did not significantly reduce morbidity although it was bacteriologically effective.
对97例患者评估了头孢唑林或安慰剂的8小时3剂量围手术期方案的效果。头孢唑林组有13例患者（27.1%）发生术后并发症，接受安慰剂的患者中有17例（34.7%）发生术后并发症。两组感染的临床部位相似，只是伤口感染（2例）和败血症（2例）仅在接受安慰剂的患者中发现。接受抗生素治疗的患者需氧菌减少，厌氧菌增加。需氧菌分离株基本未变，接受安慰剂的患者分离出的厌氧菌较少。剖宫产时观察到的抗生素水平在治疗范围内。与并发症相关的唯一危险因素是胎膜破裂。尽管该短疗程单药方案在细菌学上有效，但并未显著降低并发症发生率。
