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成年大鼠颈上神经节解离组织培养中的膜电流

Membrane currents in adult rat superior cervical ganglia in dissociated tissue culture.

作者信息

Marrion N V, Smart T G, Brown D A

出版信息

Neurosci Lett. 1987 Jun 1;77(1):55-60. doi: 10.1016/0304-3940(87)90606-9.

DOI:10.1016/0304-3940(87)90606-9
PMID:3601217
Abstract

Intracellular and whole-cell recordings were made from young adult superior cervical ganglion neurones maintained in dissociated tissue culture. The neurones possessed an M-current, A-current and calcium-activated potassium currents in addition to inward sodium and calcium currents. The properties of these currents closely resembled those observed in intact sympathetic ganglia. In contrast to neurones cultured from foetal tissue, these adult cultures exhibited consistent responses to nicotinic agonists.

摘要

在解离组织培养中,对成年幼龄颈上神经节神经元进行了细胞内和全细胞记录。这些神经元除了具有内向钠电流和钙电流外,还具有M电流、A电流和钙激活钾电流。这些电流的特性与在完整交感神经节中观察到的特性非常相似。与从胎儿组织培养的神经元不同,这些成年培养物对烟碱激动剂表现出一致的反应。

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