大鼠交感神经元中的N形电流-电压关系。

An N-shaped current-voltage relationship in rat sympathetic neurones.

作者信息

Galvan M, Sedlmeir C

出版信息

Pflugers Arch. 1983 Jun;398(1):78-80. doi: 10.1007/BF00584718.

Abstract

Neurones in the rat isolated superior cervical ganglion were voltage clamped using 2 independent microelectrodes. From a holding potential of -40mV, depolarizing voltage commands to potentials more positive than -20mV elicited outward currents. The current-voltage relationship displayed an N-characteristic with a minimum at +80 to +100mV. Replacement of the external Ca++ ions with Mn++ reversibly abolished a part of the total outward current. The results indicate that rat sympathetic neurones exhibit two potassium currents, a delayed rectifier current and a Ca++-dependent potassium current.

摘要

使用两个独立的微电极对大鼠离体颈上神经节中的神经元进行电压钳制。从 -40mV 的钳制电位开始，将去极化电压指令施加到比 -20mV 更正的电位时会引发外向电流。电流 - 电压关系呈现出 N 形特征，在 +80 至 +100mV 处有最小值。用 Mn++ 替代外部 Ca++ 离子可可逆地消除部分总外向电流。结果表明，大鼠交感神经元表现出两种钾电流，即延迟整流电流和 Ca++ 依赖性钾电流。