文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

基于 FeO 纳米粒子的 SiO/PEG 壳的磁响应性阿霉素载药材料及其对癌细胞系的作用研究。

Magnetic-Responsive Doxorubicin-Containing Materials Based on FeO Nanoparticles with a SiO/PEG Shell and Study of Their Effects on Cancer Cell Lines.

机构信息

Postovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), 620108 Ekaterinburg, Russia.

Center of Bioscience and Bioengineering, Siberian State Medical University, 634050 Tomsk, Russia.

出版信息

Int J Mol Sci. 2022 Aug 13;23(16):9093. doi: 10.3390/ijms23169093.

DOI:10.3390/ijms23169093
PMID:36012356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9409415/
Abstract

Novel nanocomposite materials based on FeO magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid-polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated.

摘要

基于 FeO 磁性纳米粒子 (MNPs) 的新型纳米复合材料被制备，这些 MNPs 被硅烷和 [(3-三乙氧基硅丙基)琥珀酸-聚乙二醇 (PEG 3000)] 共价修饰，这提供了高水平的阿霉素 (Dox) 负载。评估了在酸性和中性介质中交变磁场 (AMF) 作用下从纳米材料表面解吸 Dox 的效率。证明了它们对肿瘤细胞的高细胞毒性，以及在施加 AMF 时的药物释放，这导致细胞毒性作用的增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/9409415/e98113848bde/ijms-23-09093-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/9409415/6776c158b5ae/ijms-23-09093-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/9409415/06d20f5ee629/ijms-23-09093-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/9409415/0959a802abf1/ijms-23-09093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/9409415/bcf9c9bc618c/ijms-23-09093-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/9409415/472824a5e784/ijms-23-09093-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/9409415/e98113848bde/ijms-23-09093-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/9409415/6776c158b5ae/ijms-23-09093-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/9409415/06d20f5ee629/ijms-23-09093-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/9409415/0959a802abf1/ijms-23-09093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/9409415/bcf9c9bc618c/ijms-23-09093-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/9409415/472824a5e784/ijms-23-09093-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/9409415/e98113848bde/ijms-23-09093-g004.jpg

相似文献

[1]
Magnetic-Responsive Doxorubicin-Containing Materials Based on FeO Nanoparticles with a SiO/PEG Shell and Study of Their Effects on Cancer Cell Lines.

Int J Mol Sci. 2022-8-13

[2]
Folic acid-conjugated polyethylene glycol-coated magnetic nanoparticles for doxorubicin delivery in cancer chemotherapy: Preparation, characterization and cytotoxicity on HeLa cell line.

Hum Exp Toxicol. 2017-8

[3]
Stimuli-responsive hybrid cluster bombs of PEGylated chitosan encapsulated DOX-loaded superparamagnetic nanoparticles enabling tumor-specific disassembly for on-demand drug delivery and enhanced MR imaging.

Carbohydr Polym. 2018-10-28

[4]
A multi-controlled drug delivery system based on magnetic mesoporous FeO nanopaticles and a phase change material for cancer thermo-chemotherapy.

Nanotechnology. 2017-8-24

[5]
Poly(ethylene glycol)-modified PAMAM-Fe3O4-doxorubicin triads with the potential for improved therapeutic efficacy: generation-dependent increased drug loading and retention at neutral pH and increased release at acidic pH.

Langmuir. 2014-2-4

[6]
[Preparation and in vitro evaluation of doxorubicin-loaded magnetic iron oxide nanoparticles].

Yao Xue Xue Bao. 2013-12

[7]
SiO-coated magnetic nano-FeO photosensitizer for synergistic tumour-targeted chemo-photothermal therapy.

Colloids Surf B Biointerfaces. 2020-11

[8]
Controlled release of doxorubicin from polyethylene glycol functionalized melanin nanoparticles for breast cancer therapy: Part I. Production and drug release performance of the melanin nanoparticles.

Int J Pharm. 2019-8-12

[9]
Modified green synthesis of FeO@SiO nanoparticles for pH responsive drug release.

Mater Sci Eng C Mater Biol Appl. 2020-7

[10]
Chitosan, Polyethylene Glycol and Polyvinyl Alcohol Modified MgFeO Ferrite Magnetic Nanoparticles in Doxorubicin Delivery: A Comparative Study In Vitro.

Molecules. 2021-6-25

引用本文的文献

[1]
The Application of Ultrasmall Gold Nanoparticles (2 nm) Functionalized with Doxorubicin in Three-Dimensional Normal and Glioblastoma Organoid Models of the Blood-Brain Barrier.

Molecules. 2024-5-24

[2]
Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy.

Med Rev (2021). 2023-3-17

[3]
Magnetic Nanocomposite Materials Based on FeO Nanoparticles with Iron and Silica Glycerolates Shell: Synthesis and Characterization.

Int J Mol Sci. 2023-7-29

[4]
Metal and Metal Oxides Nanoparticles and Nanosystems in Anticancer and Antiviral Theragnostic Agents.

Pharmaceutics. 2023-4-7

[5]
Iron Oxide@Mesoporous Silica Core-Shell Nanoparticles as Multimodal Platforms for Magnetic Resonance Imaging, Magnetic Hyperthermia, Near-Infrared Light Photothermia, and Drug Delivery.

Nanomaterials (Basel). 2023-4-12

[6]
Study on Doxorubicin Loading on Differently Functionalized Iron Oxide Nanoparticles: Implications for Controlled Drug-Delivery Application.

Int J Mol Sci. 2023-2-24

[7]
Smart Nanoparticle-Based Platforms for Regulating Tumor Microenvironment and Cancer Immunotherapy.

Adv Healthc Mater. 2023-3

[8]
Effect of the Silica-Magnetite Nanocomposite Coating Functionalization on the Doxorubicin Sorption/Desorption.

Pharmaceutics. 2022-10-24

[9]
Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis.

Front Pharmacol. 2022-10-18

[10]
Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin.

Materials (Basel). 2022-10-13

本文引用的文献

[1]
Stimuli-Responsive Drug Delivery of Doxorubicin Using Magnetic Nanoparticle Conjugated Poly(ethylene glycol)--Chitosan Copolymer.

Int J Mol Sci. 2021-12-6

[2]
Smart Design of a pH-Responsive System Based on pHLIP-Modified Magnetite Nanoparticles for Tumor MRI.

ACS Appl Mater Interfaces. 2021-8-11

[3]
Chitosan, Polyethylene Glycol and Polyvinyl Alcohol Modified MgFeO Ferrite Magnetic Nanoparticles in Doxorubicin Delivery: A Comparative Study In Vitro.

Molecules. 2021-6-25

[4]
Stimuli-responsive mesoporous silica nanoparticles: A custom-tailored next generation approach in cargo delivery.

Mater Sci Eng C Mater Biol Appl. 2021-5

[5]
A Smart Hyperthermia Nanofiber-Platform-Enabled Sustained Release of Doxorubicin and 17AAG for Synergistic Cancer Therapy.

Int J Mol Sci. 2021-3-3

[6]
Multifunctional nanostructured drug delivery carriers for cancer therapy: Multimodal imaging and ultrasound-induced drug release.

Colloids Surf B Biointerfaces. 2021-4

[7]
Ultrasmall Fe@FeO nanoparticles as T-T dual-mode MRI contrast agents for targeted tumor imaging.

Nanomedicine. 2021-2

[8]
Variation in tumor pH affects pH-triggered delivery of peptide-modified magnetic nanoparticles.

Nanomedicine. 2021-2

[9]
Efficient uptake and retention of iron oxide-based nanoparticles in HeLa cells leads to an effective intracellular delivery of doxorubicin.

Sci Rep. 2020-6-29

[10]
Targeted Dendrimer-Coated Magnetic Nanoparticles for Selective Delivery of Therapeutics in Living Cells.

Molecules. 2020-5-10

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索