Department of Medicine, Mount Auburn Hospital, Beth Israel Lahey Health, Cambridge, MA 02138, USA.
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Int J Mol Sci. 2022 Aug 14;23(16):9122. doi: 10.3390/ijms23169122.
Studies have demonstrated the link between vitamin-D-related genetic variations and nonskeletal outcomes. We aimed to identify all available data on the association of vitamin-D-related genetic variations with nonalcoholic fatty liver disease (NAFLD).
Potentially eligible studies were identified from Embase and Medline databases from inception to June 2022 using a search strategy that comprised terms for "Vitamin D" and "NAFLD". Eligible studies must report the association between vitamin D-related genetic variations and presence, severity or response to treatment of NAFLD. Data were extracted from each eligible study.
A total of 3495 articles were identified. After a systematic review, twelve studies were included. A total of 26 genetic variations were identified. Presence of NAFLD was associated with variations of (rs222054, rs222020, rs10011000, rs7041), (rs2228570, rs11168287, rs10783219, rs4752), (rs3787557, rs6068816, rs2296241, rs2248359) and (rs4646536). Severity of NAFLD was associated with variations of (rs4588), (rs2228570, rs4334089), (rs10741657), (rs1544410, rs3829251, rs12785878) and (rs3787557, rs6068816, rs6097809, rs6127119, rs2248359, rs3787554, rs4809960, rs6022999). Response to calcitriol treatment was associated with variation of (rs10735810).
Multiple vitamin D-related genetic variations were associated with NAFLD, indicating the role of vitamin D in the pathogenesis of NAFLD.
研究已经证实了维生素 D 相关基因变异与非骨骼结局之间的联系。我们旨在确定所有关于维生素 D 相关基因变异与非酒精性脂肪性肝病 (NAFLD) 之间关联的可用数据。
从 Embase 和 Medline 数据库中，使用包含“维生素 D”和“NAFLD”的检索策略，从成立到 2022 年 6 月检索潜在的合格研究。合格的研究必须报告维生素 D 相关基因变异与 NAFLD 的存在、严重程度或对治疗的反应之间的关系。从每个合格的研究中提取数据。
共确定了 3495 篇文章。经过系统评价，纳入了 12 项研究。共确定了 26 个基因变异。存在 NAFLD 与以下基因变异有关：（rs222054、rs222020、rs10011000、rs7041），（rs2228570、rs11168287、rs10783219、rs4752），（rs3787557、rs6068816、rs2296241、rs2248359）和（rs4646536）。NAFLD 的严重程度与以下基因变异有关：（rs4588），（rs2228570、rs4334089），（rs10741657），（rs1544410、rs3829251、rs12785878）和（rs3787557、rs6068816、rs6097809、rs6127119、rs2248359、rs3787554、rs4809960、rs6022999）。对骨化三醇治疗的反应与变异（rs10735810）有关。
多种维生素 D 相关基因变异与 NAFLD 有关，表明维生素 D 在 NAFLD 的发病机制中起作用。
