Gentile Maria Teresa, Muto Gianluca, Lus Giacomo, Lövblad Karl-Olof, Svenningsen Åsa Fex, Colucci-D'Amato Luca
Laboratory of Cellular and Molecular Neuropathology, Department of Environmental, Biological and Pharmaceutical Science and Technology, University of Campania "L. Vanvitelli", 81100 Caserta, Italy.
Division of Diagnostic and Interventional Neuroradiology, Geneva University Hospitals, 1205 Geneva, Switzerland.
J Clin Med. 2022 Aug 9;11(16):4643. doi: 10.3390/jcm11164643.
Multiple sclerosis is a chronic disease of the central nervous system characterized by demyelination and destruction of axons. The most common form of the disease is the relapsing-remitting multiple sclerosis in which episodic attacks with typical neurological symptoms are followed by episodes of partial or complete recovery. One of the underestimated factors that contribute to the pathogenesis of multiple sclerosis is excessive angiogenesis. Here, we review the role of angiogenesis in the onset and in the development of the disease, the molecular mechanisms underlying angiogenesis, the current therapeutic approaches, and the potential therapeutic strategies with a look at natural compounds as multi-target drugs with both neuroprotective and anti-angiogenic properties.
多发性硬化症是一种中枢神经系统的慢性疾病，其特征为脱髓鞘和轴突破坏。该疾病最常见的形式是复发缓解型多发性硬化症，其中典型神经症状的发作性发作之后是部分或完全恢复的阶段。促成多发性硬化症发病机制的一个被低估的因素是过度血管生成。在此，我们综述血管生成在该疾病的发病和发展中的作用、血管生成的分子机制、当前的治疗方法以及潜在的治疗策略，并着眼于天然化合物作为具有神经保护和抗血管生成特性的多靶点药物。
