Molecular Profile and Prognostic Value of Mutations in Intrahepatic Cholangiocarcinoma: A Genomic Database Analysis.

BACKGROUND

Recent years have witnessed the advent of molecular profiling for intrahepatic cholangiocarcinoma (iCCA), and new techniques have led to the identification of several molecular alterations. Precision oncology approaches have been widely evaluated and are currently under assessment, as shown by the recent development of a wide range of agents targeting Fibroblast Growth Factor Receptor (FGFR) 2, Isocitrate Dehydrogenase 1 (IDH-1), and BRAF. However, several knowledge gaps persist in the understanding of the genomic landscape of this hepatobiliary malignancy.

METHODS

In the current study, we aimed to comprehensively analyze clinicopathological features of -mutated iCCA patients in public datasets to increase the current knowledge on the molecular and biological profile of iCCA.

RESULTS

The current database study, including 772 iCCAs, identified mutations in 120 cases (15.7%). According to our analysis, no differences in terms of overall survival and relapse-free survival were observed between -mutated and wild-type patients receiving radical surgery. In addition, IDH1, PBRM1, and ARID1A mutations were the most commonly co-altered genes in -mutated iCCAs.

CONCLUSIONS

The genomic characterization of iCCA is destined to become increasingly important, and more efforts aimed to implement iCCA genomics analysis are warranted.