Porreca Veronica, Barbagallo Cristina, Corbella Eleonora, Peres Marco, Stella Michele, Mignogna Giuseppina, Maras Bruno, Ragusa Marco, Mancone Carmine
Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Section of Biology and Genetics, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
Cancers (Basel). 2024 Aug 20;16(16):2889. doi: 10.3390/cancers16162889.
Intrahepatic cholangiocarcinoma (iCCA) is recognized worldwide as the second leading cause of morbidity and mortality among primary liver cancers, showing a continuously increasing incidence rate in recent years. iCCA aggressiveness is revealed through its rapid and silent intrahepatic expansion and spread through the lymphatic system leading to late diagnosis and poor prognoses. Multi-omics studies have aggregated information derived from single-omics data, providing a more comprehensive understanding of the phenomena being studied. These approaches are gradually becoming powerful tools for investigating the intricate pathobiology of iCCA, facilitating the correlation between molecular signature and phenotypic manifestation. Consequently, preliminary stratifications of iCCA patients have been proposed according to their "omics" features opening the possibility of identifying potential biomarkers for early diagnosis and developing new therapies based on personalized medicine (PM). The focus of this review is to provide new and advanced insight into the molecular pathobiology of the iCCA, starting from single- to the latest multi-omics approaches, paving the way for translating new basic research into therapeutic practices.
肝内胆管癌（iCCA）在全球范围内被公认为是原发性肝癌中导致发病和死亡的第二大主要原因，近年来其发病率持续上升。iCCA的侵袭性表现为在肝内迅速且隐匿地扩散，并通过淋巴系统转移，导致诊断延迟和预后不良。多组学研究整合了来自单一组学数据的信息，能更全面地理解所研究的现象。这些方法正逐渐成为研究iCCA复杂病理生物学的有力工具，有助于分子特征与表型表现之间的关联。因此，已根据iCCA患者的“组学”特征提出了初步分层，为识别早期诊断的潜在生物标志物以及基于个性化医疗（PM）开发新疗法开辟了可能性。本综述的重点是从单一组学方法到最新的多组学方法，为iCCA的分子病理生物学提供新的和先进的见解，为将新的基础研究转化为治疗实践铺平道路。
