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减少疑似输尿管结石症状患者非增强计算机断层扫描使用的潜在标志物。

Potential Markers to Reduce Non-Contrast Computed Tomography Use for Symptomatic Patients with Suspected Ureterolithiasis.

作者信息

Avda Yuval, Shpunt Igal, Modai Jonathan, Leibovici Dan, Berkowitz Brian, Shilo Yaniv

机构信息

Department of Urology, Kaplan Medical Center, Affiliated with the Hebrew University, Rehovot 7661041, Israel.

Department of Earth and Planetary Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.

出版信息

J Pers Med. 2022 Aug 21;12(8):1350. doi: 10.3390/jpm12081350.

Abstract

Most patients with ureterolithiasis are managed successfully with conservative treatment. In this context, delineation of clinical risk factors that identify patients with low risk for surgical intervention may reduce use of Non-Contrast Computed Tomography (NCCT). Here, emergency department patient files from a 14-month period were reviewed retrospectively, to identify patients who underwent NCCT and showed a ureteral stone. Demographic, clinical and laboratory information was collected. Patients were grouped to either requiring surgical intervention (Group 1) or having successful conservative management (Group 2). The cohort included 368 patients; 36.1% ultimately required surgical intervention (Group 1) and 63.9% were successfully treated conservatively (Group 2). On univariate analysis, patients who required surgical intervention were older, had longer duration of symptoms, had history of urolithiasis and surgical intervention for urolithiasis and had higher serum creatinine levels. Multivariate analysis identified the following risk factors associated with surgical intervention: creatinine >1.5 mg/dL, duration of symptoms ≥ 1.5 days and age > 45 years. Patients with 0, 1, 2 or 3 of the identified risk factors had 19%, 32%, 53% and 73% likelihood, respectively, of surgical intervention. Incorporating these data may reduce the use of NCCT scans in patients who are likely to pass a stone via conservative management.

摘要

大多数输尿管结石患者通过保守治疗可成功治愈。在此背景下,明确那些手术干预风险较低的患者的临床风险因素,可能会减少非增强计算机断层扫描(NCCT)的使用。在此,我们回顾性分析了14个月期间急诊科的患者档案,以确定接受NCCT并显示有输尿管结石的患者。收集了人口统计学、临床和实验室信息。患者被分为需要手术干预的患者(第1组)或保守治疗成功的患者(第2组)。该队列包括368名患者;最终36.1%的患者需要手术干预(第1组),63.9%的患者通过保守治疗成功治愈(第2组)。单因素分析显示,需要手术干预的患者年龄较大、症状持续时间较长、有尿石症病史和尿石症手术干预史,且血清肌酐水平较高。多因素分析确定了与手术干预相关的以下风险因素:肌酐>1.5mg/dL、症状持续时间≥1.5天和年龄>45岁。具有0、1、2或3个已确定风险因素的患者,手术干预的可能性分别为19%、32%、53%和73%。纳入这些数据可能会减少对那些可能通过保守治疗排出结石的患者进行NCCT扫描的次数。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/9410145/7f37b5708a94/jpm-12-01350-g001.jpg

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