Hafez Wael, Ahmed Shougyat, Abbas Nihad, Ahmed Kamran, Kamran Samera, Arya Arun, Rao Srinivasa Raghu, Abdelshakor Mahmoud, Ali Sara, Sebastian Honeymol, Tariq Mishal, Lal Kumar, Abdelrahman Ahmed
NMC Royal Hospital, Abu Dhabi P.O. Box 35233, United Arab Emirates.
The Medical Research Division, Department of Internal Medicine, The National Research Center, Cairo 12622, Egypt.
Life (Basel). 2022 Jul 29;12(8):1157. doi: 10.3390/life12081157.
(1) Background: The association between ABO blood groups and COVID-19 outcomes was investigated in several studies. The results were controversial. This study aimed to explore the association between ABO blood groups and COVID-19 outcomes. (2) Methods: This retrospective study included 303 COVID-19 patients treated at the NMC Royal Hospital in the United Arab Emirates between 8 April 2020 and 30 June 2020. (3) Results: The mean age of patients included in the study was 39.3 ± 10.7 years, and 72.9% of patients were males. The prevalence of blood groups O, A, B, and AB was 40.3%, 27.7%, 25.1%, and 6.9%, respectively. The correlation between ABO blood groups and COVID-19 outcomes was insignificant except in the AB group, with significantly higher odds of disease severity. Increased age, higher body mass index (BMI), and being of male gender increased the risk for pneumonia among all blood groups. Both increased age and higher BMI increased the risk of mortality, and increased age increased the risk of disease severity. Troponin and platelet counts were significantly different in the A group compared to the non-A groups. Time to viral clearance was not different among blood groups. However, adjustment for Rh groups resulted in a significantly shorter time in the B group. (4) Conclusions: There was no significant association between ABO blood groups and COVID-19 outcomes, with the exception of group AB.
(1) 背景：多项研究调查了ABO血型与新冠病毒疾病（COVID-19）结局之间的关联。结果存在争议。本研究旨在探讨ABO血型与COVID-19结局之间的关联。(2) 方法：这项回顾性研究纳入了2020年4月8日至2020年6月30日在阿拉伯联合酋长国NMC皇家医院接受治疗的303例COVID-19患者。(3) 结果：纳入研究的患者平均年龄为39.3±10.7岁，72.9%的患者为男性。O、A、B和AB血型的患病率分别为40.3%、27.7%、25.1%和6.9%。除AB血型组外，ABO血型与COVID-19结局之间的相关性不显著，AB血型组疾病严重程度的几率显著更高。在所有血型中，年龄增加、体重指数（BMI）升高和男性性别会增加患肺炎的风险。年龄增加和BMI升高均会增加死亡风险，年龄增加还会增加疾病严重程度的风险。与非A血型组相比，A血型组的肌钙蛋白和血小板计数存在显著差异。各血型之间的病毒清除时间没有差异。然而，对Rh血型进行调整后，B血型组的时间显著缩短。(4) 结论：除AB血型组外，ABO血型与COVID-19结局之间无显著关联。
