Madam Ayman Al, Ahmed Wasim, Al Obaidli Ali Abdul Kareem, Smith Edward R, Holt Stephen G
SEHA Kidney Care, Central Unit, Abu Dhabi, United Arab Emirates.
University of Melbourne, Melbourne, Victoria, Australia.
Saudi J Kidney Dis Transpl. 2022 May-Jun;33(3):413-417. doi: 10.4103/1319-2442.385964.
Some epidemiological data have implicated blood groups in susceptibility to coronavirus disease 2019 (COVID-19) infection. We were interested to see if there was any apparent effect of different ABO blood groups on susceptibility to COVID-19 infection in unvaccinated hemodialysis (HD) patients, as they had a high rate of mortality from this infection. Blood group O has been suggested to be protective against COVID-19 infection; however, since the ABO frequency is affected by ethnicity, we looked at infection frequency and blood group and corrected the expected frequency for the ethnicity of our cohort. We examined 249 HD patients presenting with a positive COVID-19 polymerase chain reaction regarding their ABO blood group and compared the ABO frequencies with published data for the United Arab Emirates (UAE), as well as international and historical ABO data on dialysis frequency. Although there was an apparent protective effect of blood group O when we compared blood group frequencies with the UAE data, this disappeared when corrected for ethnicity. We concluded that any association of the ABO blood group with COVID-19 infection is unlikely to be of major importance and should not be used to reassure patients that they are mildly protected against COVID-19 without vaccination.
一些流行病学数据表明血型与2019冠状病毒病（COVID-19）感染的易感性有关。我们想了解不同的ABO血型对未接种疫苗的血液透析（HD）患者感染COVID-19的易感性是否有明显影响，因为他们因这种感染而死亡率很高。有人提出O型血对COVID-19感染有保护作用；然而，由于ABO血型频率受种族影响，我们研究了感染频率和血型，并根据我们队列人群的种族校正了预期频率。我们检查了249名COVID-19聚合酶链反应呈阳性的HD患者的ABO血型，并将ABO血型频率与阿拉伯联合酋长国（UAE）公布的数据以及透析频率的国际和历史ABO数据进行了比较。当我们将血型频率与阿联酋数据进行比较时，O型血似乎有保护作用，但在校正种族因素后，这种作用消失了。我们得出结论，ABO血型与COVID-19感染之间的任何关联不太可能具有重要意义，并且不应以此向患者保证他们在未接种疫苗的情况下对COVID-19有轻度保护。
