Mitsiou Maria, Dimitros Eleftherios, Roumeliotis Stefanos, Liakopoulos Vassilios, Kouidi Evangelia, Deligiannis Asterios
Laboratory of Sports Medicine, Aristotle University of Thessaloniki, 57001 Thessaloniki, Greece.
Division of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Life (Basel). 2022 Aug 20;12(8):1276. doi: 10.3390/life12081276.
This study aimed to examine the effect of an intradialytic exercise program in combination with music on heart rate variability (HRV) indices and functional capacity in patients on maintenance hemodialysis (HD). Methods: Forty HD patients were randomized to four training groups for six months: the combined music and exercise group (Group A), the exercise group (Group B), the music group (Group C), and the control group (Group D). At baseline and after 6 months, all participants underwent both short- (for 30 min) and long- (for 24 h) term measurements of HRV and functional capacity assessment with a 6 min walking test (6MWT). Patients of groups A and C listened to preferred music. Results: Long-term HRV analysis showed that standard deviation of all normal-to-normal RR intervals (SDNN) and the square root of the mean squared differences of successive RR intervals (rMSSD) were significantly higher at the end of the study in groups A (by 13.2% and 47.3%), B (by 15.1% and 50%), and C (by 9.0% and 30.1%), compared to group D (p < 0.05). Values of rMSSD and percentage of RR intervals differing by more than 50 ms from the preceding RR interval (pNN50) were elevated in groups A (by 35.6% and 142.9%), B (by 36.1% and 75%), and C (by 15.2% and 28.6%), compared to baseline measurements (p < 0.05). Also, pNN50 was increased in group A compared to groups B (by 21.4%), C (by 88.9%), and D (by 142.9%) (p < 0.05). Similar results were noted by short-term HRV analysis. Functional capacity was improved at the end of the 6-month study in groups A (by 20.3% and 25.7%) and B (by 15.8% and 21.1%) compared to groups C and D (p < 0.05). Conclusions: Intradialytic exercise combined with music-listening can improve the functional capacity and cardiac autonomic nervous system activity in hemodialysis patients.
本研究旨在探讨透析期间运动计划联合音乐对维持性血液透析（HD）患者心率变异性（HRV）指标及功能能力的影响。方法：40例HD患者被随机分为4个训练组，为期6个月：音乐与运动联合组（A组）、运动组（B组）、音乐组（C组）和对照组（D组）。在基线期和6个月后，所有参与者均接受了HRV的短期（30分钟）和长期（24小时）测量，并通过6分钟步行试验（6MWT）进行功能能力评估。A组和C组患者听喜欢的音乐。结果：长期HRV分析显示，与D组相比，研究结束时A组（分别提高13.2%和47.3%）、B组（分别提高15.1%和50%）和C组（分别提高9.0%和30.1%）的所有正常RR间期标准差（SDNN）和连续RR间期均方根差（rMSSD）显著更高（p<0.05）。与基线测量相比，A组（分别提高35.6%和142.9%）、B组（分别提高36.1%和75%）和C组（分别提高15.2%和28.6%）的rMSSD值和RR间期与前一个RR间期相差超过50毫秒的百分比（pNN50）升高（p<0.05）。此外，与B组（提高21.4%）、C组（提高88.9%）和D组（提高142.9%）相比，A组的pNN50升高（p<o.05）。短期HRV分析也得出了类似结果。与C组和D组相比，6个月研究结束时A组（分别提高20.3%和25.7%）和B组（分别提高15.8%和21.1%）的功能能力得到改善（p<0.05）。结论：透析期间运动联合听音乐可改善血液透析患者的功能能力和心脏自主神经系统活动。
